Both the high-dose and the low-dose colonies grew more slowly than the undosed ones, gaining 8-12% less weight on average.
Imagine a doctor telling you she is deliberately prescribing an excessive dose of a drug because she prescribed too weak a dose the last time.
Alnylam's CEO, John Maraganore, says another piece of good news is the injections didn't cause any side effects, at least not from the single dose the animals got.
But although the high, 80-milligram dose of Lipitor cut heart attacks compared to the 10-mg starting dose, the increased dose did not cut down on the total number of deaths.
The FDA should immediately conduct a review of all generic drug approvals in this class and others to determine what other approvals were made with the same faulty approach of assuming that if one dose worked then the higher dose or lower dose must work the same.
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The study, funded by Pfizer (nyse: PFE - news - people ) and called Treating New Targets, or TNT, showed that the top dose of Lipitor decreased the risk of heart attacks and strokes in people with stable heart disease, compared to the lowest dose of the same drug.
In the first generation scanners, the dose was estimated to be up to 600 chest x-rays, but more recent technology has reduced the dose to nearly one fifth of the original estimates.
The caps tend to be much bigger than the dose for the heaviest loads, he said.
The only difference was the dose of atorvastatin and the resulting greater lowering of LDL at the high dose.
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All these side effects can be reversed by lowering the dose of the medication, changing the medication, or stopping it altogether.
The higher the dose, the greater the pneumonia risk, his team reported in the Oct. 27 Journal of the American Medical Association.
This allows doctors to boost the dose at the core of the tumor while giving lower doses at the edges, preserving healthy tissue.
But Schering-Plough and Merck will need to convince doctors that adding Zetia is safer than just raising the dose of the very popular statins.
In MS patients, the dose eliminates the immune cells entirely, forcing a new immune system to be built from scratch which should not attack the nerves.
Even in the cases where the patients saw lower decreases in cholesterol, taking Zetia allowed them to lower the dose of the statin they were on without having their cholesterol go up.
To pull out the most relevant number from that: the decline in distance walked among patients treated with a high dose of the drug was about a tenth as much as for those who were on the low dose.
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It appears, however, that adding Zetia to a low dose of a statin, such as Zocor or Lipitor, is as effective as using the higher dose of the statin.
The key difference in dose for the Mars mission is that dose limits for civilians are ten times lower than for workers, which include astronauts.
The change also applies to the top dose of The combo pill Vytorin, which contains simvastatin and a second drug.
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The first dose of the MMR vaccine should ideally be given to children between 12 to 13 months of age.
The studies were done with rabbits, which were given the same dose of the active ingredient SPL7013 that is found in VivaGel.
That means the highest dose of the medicine that the company has tested, 80 mg, will probably not be approved in the near term.
Worse, one in 250 patients taking the highest dose of the medicine had serious muscle-weakening side effects, which in rare cases can be lethal.
In pure numbers, more cancers will result, he said, from the increased dose to the much larger population exposed as fallout spread across the world.
Uptake is now as high as ever with more than 91% of children under the age of two getting the first dose of the jab in England.
ORLANDO, FLA. - A Pfizer -funded study showed the top dose of the company's cholesterol drug Lipitor stopped plaque from accumulating in arteries but did not reverse its buildup.
According to the NHS, the first dose of the measles, mumps and rubella (MMR) vaccine should ideally be given to babies who are between 12 to 13 months old.
The new Crestor label also contains a boldfaced instruction not to prescribe the highest dose of the drug (40 milligrams) unless patients have not been sufficiently helped by lower doses.
The 700 patients in the ENHANCE trial, who all had a genetic disease causing their levels of bad cholesterol to spike without treatment, were all on the top dose of the cholesterol-lowering drug Zocor.
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