But one thing is clear: almost all of the evidence cited by anti-chemical campaigners is based on research linking phthalates to reproductive problems in rodents exposed to dose levels far higher than any human might face.
Others fill the prescriptions and dose themselves at levels lower than prescribed, taking a half pill, say, instead of a whole one.
The backscatter machine "delivers an extremely low dose of ionizing radiation" with levels "below the acceptable limits, " the report stated.
In the circadian-gene mutants, however, the enzyme's activity stays steady after a dose of the drug, so tyramine levels remain low.
Such a physician might be able to guide the parents of colicky babies through a difficult time that is (mercifully) usually transient, and could also help patients requiring hormone replacement therapy (whether for low thyroid hormone levels or low testosterone levels) decide what replacement dose makes sense, and reach a conclusion that would be informed by numeric criteria but not exclusively defined by it.
FORBES: Are doctors over-responsive to patients -- or not attentive enough? (Answer: yes.)
Eventually there could be drugs activated by the patient's own body, with, for instance, a chip that could sense when a diabetic has high levels of glucose and release the required dose of insulin.
If researchers determine different metabolite levels are better, or examine a different metabolite to adjust the dose, there is no infringement.
FORBES: Mayo Clinic Case Asks If A Doctor's Method Can Be Patented
The graphic below shows levels of acute exposure and the corresponding health effects based on total dose occurring in in a single day.
The 700 patients in the ENHANCE trial, who all had a genetic disease causing their levels of bad cholesterol to spike without treatment, were all on the top dose of the cholesterol-lowering drug Zocor.
Even at the elevated levels found off the coast, the amount of caffeine is well below a lethal dose for marine life, Portland State said.
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