Ms. TRACY ZIMMERMAN (Scientist, Alnylam Pharmaceuticals): We dosed six animals at each doselevel, and then we had a control group, which was just treated with saline alone.
After all, she noted, only 1% of demand for Pfizer's Lipitor is at the 80-mg level, and the 40-mg dose of Crestor appears to be at least as powerful as the 80-mg dose of Lipitor.
The question is whether one can find a dose that prevents thromboembolic strokes with the new generation anticoagulants at an acceptable level of bleeding.