"This study is still five times below the highest dose at which no adverse effect has been found, " he says.
The part of this line above 10 rem (0.1 Sv) certainly supports this idea, although doubling the dose does not double the effect like is commonly thought.
This time the agency asked for a new study to test the effect of a high dose of the drug on heart rhythm.
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Although it takes three to four years for the shots to reach their full effect, after which the dose is tapered down and eventually stopped, people often experience relief within a couple of months after beginning allergy shots.
But doctors are concerned about the plans, saying the dose may be too low to have any effect and that it may be difficult to monitor patients buying statins.
Many ads feature kids, like the recent Marriott International spots that show a young guest trying on, and misplacing, her father's shoes. (A Marriott employee comes to the rescue with a new pair.) Sometimes they deliver a dose of schmaltz, using music to great effect.
"It was a safe dose of a kids' medicine, with side effect of sleepiness, " he says.
So, dose for dose, alcohol has a greater and more intense effect in women.
The effect of echinacea may vary according to the dose, how it's prepared, and even whether it's taken on an empty stomach, Dr. Firshein says.
This effect increased at higher doses, suggesting a dose-response association.
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When Bristol launched the face-off, it pitted a less-potent Pravachol pill against the highest-dose Lipitor pill, aiming to show that higher doses didn't have much additional effect.
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