Today Norton's "dose-dense" regimen is common practice for certain breast cancer patients at high risk of relapse after surgery.
Both the high-dose and the low-dose colonies grew more slowly than the undosed ones, gaining 8-12% less weight on average.
Change in electrical potential was measured before and after application and a dose-response curve was constructed with R2 value of 99.92%.
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"You cannot give dose-dense chemotherapy without Neupogen, " says Marc Citron, a professor at Albert Einstein College of Medicine in Brookeville, N.
Those already on the drugs might benefit from a higher dose--a spate of recent studies has shown that more statins means fewer heart attacks.
There have been widespread concerns that if a patient stops taking the drug suddenly - or changes dose - they are vulnerable to suicidal feelings.
The assumption that Sr-90 and childhood cancer are correlated is best supported for a supralinear dose-response, meaning the greatest per-dose risks are at the lowest doses.
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Preliminary results were encouraging, and even showed a benefit on reducing deaths in one dose--although experts warn to view that as preliminary until a larger study is done.
This effect increased at higher doses, suggesting a dose-response association.
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In a dose-ranging study presented at the American College of Cardiology in March, patients who received the top 120 milligram dose of ETC-1002 saw their LDL decrease by a still-respectable 27%.
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"The absence of a dose-response curve was disappointing, " says Jeffrey Cummings of UCLA. Moreover, he noted that the drug only very modestly reduced levels of a nasty protein called tau in the spinal fluid.
One low-dose statin - simvastatin - is available in a low dose to buy from the pharmacist.
"If used widely, this inexpensive, fixed-dose artemisinin-based combination antimalarial could make important contributions to 'rolling back malaria', " they wrote.
The company says its Single Pose Secure scanner uses an extremely low-dose X-ray, equivalent to spending two minutes on an aircraft.
Rapiscan backscatter scanners use low-dose x-rays to do the same.
Since the groundbreaking study, many have turned to lower-dose therapies or alternatives such as low-dose vaginal rings.
In only one of the trials did the use of stem-cell support and high-dose chemotherapy appear to prolong life more effectively than conventional low-dose treatment.
In the study that spent two years tracking 4, 162 patients who had already survived a severe heart attack, those on high-dose Lipitor were 16% less likely to die or have heart attacks than those on standard-dose Pravachol.
But 13% of patients on the high-dose group discontinued because of side effects during the first year, compared with 9% in the lower-dose group and 7.2% on placebo.
Nissen of the Cleveland Clinic, compared the 80-milligram dose of Lipitor to the 40-mg dose of Bristol's Pravachol.
The effects of aspirin were independent of age, and sex, and were also seen with a low-dose, slow-release formulation of aspirin designed to inhibit platelets but to have little systemic bioavailability.
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The absence of the 80-mg dose may raise another fear with investors: that the 40-mg dose would also not reach the U.S. market.
They all had to take a 10-day dose of anti-viral medication.
Forest says clinical trials involving 1, 100 patients show that a low, 10-milligram dose of Lexapro is as effective at relieving depression as a 40-mg dose of Celexa.
The larger point is that there is now a surprisingly long list of respected figures who have said a "helicopter drop" - a dose of money-financed fiscal stimulus which is never paid back - is worth talking about, even if they do not necessarily want to do it right away.
In the 4, 162-person PROVEIT study, Harvard cardiologists found that patients hospitalized for heart attacks or unstable angina who took a 80-milligram dose of Lipitor were 16% less likely to suffer heart attacks or other cardiovascular "events" over two years than those who took a lower dose of Bristol-Myers Squibb 's (nyse: BMY - news - people ) Pravachol.
After all, she noted, only 1% of demand for Pfizer's Lipitor is at the 80-mg level, and the 40-mg dose of Crestor appears to be at least as powerful as the 80-mg dose of Lipitor.
But although the high, 80-milligram dose of Lipitor cut heart attacks compared to the 10-mg starting dose, the increased dose did not cut down on the total number of deaths.
GSK, comes in an innovative, multi-dose inhaler that is breath-activated and easier to use.
The findings indicated the relationship between birth weight and pollution was dose related - the higher the exposure, the lower the average birth weight.
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