By contrast, Roche recently doubled the size of a trial testing a compound in patients with early-stage disease.
Peter Reynolds, chief executive of Ovarian Cancer Action, said most women with ovarian cancer were currently diagnosed with later stage disease.
Analysis of the data showed a 24% increased risk of advanced cancer and 49% increased risk of early-stage disease for night workers compared with those who worked during the day.
Indeed, there are studies showing that most women diagnosed with early stage disease in their 40s are diagnosed when they seek medical help after feeling a breast lump while dressing or showering.
Donepezil was also more effective than another common Alzheimer's drug, memantine (Namenda), in patients with later-stage disease, although memantine still showed some benefit, according to the study published this week in The New England Journal of Medicine.
To take one of many examples, a group of researchers at the American Cancer Society looked at 533, 715 women with breast cancer, and asked: When those women were first diagnosed with breast cancer, were they diagnosed with early-stage or late-stage disease?
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The five-year survival rate for those diagnosed at a local stage of disease is 91 percent.
Epogen's main use is to treat anemia in patients with kidney failure, also known as end-stage renal disease.
Heart transplants are the last resort for end-stage heart disease, but there aren't enough organs to go around.
Congress expanded Medicare in 1972 to cover dialysis for all patients with end-stage renal disease, then jiggered the reimbursement rates to encourage the use of home dialysis techniques that were theoretically less expensive.
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This suggests that low overall breast cancer survival in Denmark - the only country that had not fully implemented a national breast screening programme before 2007 - was due to women being diagnosed at a later stage of disease.
He said there were important clinical implications, as the benefit of the treatment was conferred to the group of patients with the highest risks for cardiovascular events, and the effect persisted, even at a rather late stage of disease.
"There's no question that we're approaching the terminal stage of the disease, " says Black.
Approximately 1 million patients suffer from Class IV heart failure, the most severe stage of the disease.
About 7, 000 UK people develop stomach cancer each year and most have an advanced stage of the disease.
The campaign aims to increase the number of cases detected at the earliest stage of the disease by over 25% by 2016.
"At this stage of the disease, if the patient can cooperate with being washed or toileted, that can make a big difference, " she says.
By the time a biopsy confirms the diagnosis, the disease is in its chronic stage, often with severe scarring of the liver and the threat of cancer and death.
Although the combination of donepezil and memantine -- a common strategy in the U.S., but not the U.K. -- had no added benefit, each drug had "independent positive effects, " says Howard, who advises patients at this stage of the disease to continue taking both drugs if possible.
Even patients with widely disseminated stage 3 or 4 disease can often be cured.
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The drug was being tested in patients with stage 4 chronic kidney disease and type 2 diabetes.
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Unrealistic expectations of modern medicine to achieve a cure, especially in some patients with cancer, post-cardiac arrest, end-stage cardiac or pulmonary disease and major stroke.
"To me, he looked like someone who was at the end stage of a long disease process, " Senneff said, adding that Murray told him that he was treating Jackson for dehydration.
Although the product has been shown to be safe, there is no evidence whatsoever that it should be taken by anyone who does not have mild or early stage Alzheimer's disease, Hughes said.
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Researchers said the new findings for both Afinitor and pertuzumab were sufficient to begin testing it in earlier-stage cancer, before the disease spreads to other parts of the body.
John Shepherd, a professor of obstetrics and gynaecology at St Bartholomew's, told the Sunday Telegraph the success of Britain's cervical cancer screening programme meant that the disease was being caught in its early stage in many more patients.
Men may be cured of prostate cancer if the disease is found and treated at an early stage.
Late last week, Millennium Pharmaceuticals (nasdaq: MLNM - news - people ) disclosed in a regulatory filing that MLN-02, a treatment for Crohn's disease, was effective in a mid-stage clinical trial.
Chi-Med was able to skip the early-stage trial with its Crohn's disease drug candidate because its active ingredient, the herb andrographolide, has been used in China for decades to treat respiratory infections and inflammation.
Stage IV breast cancer is considered a systemic disease, meaning it is no longer contained in one area but is throughout the body.
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