Drug resistance and disease progression have been observed all for anticancer drugs that target specific genetic alterations.
Something similar happened with breast cancer: Avastin won the Food and Drug Administration's approval after studies suggested it delayed disease progression.
Genetic diseases also pose significant challenges in the design of clinical trials, particularly in identifying biomarkers and other surrogates for disease progression.
The latest study tracked the patients' disease progression over a two-year period.
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In MS, beta-interferon, the most effective treatment produced so far, holds back the number of attacks but does not prevent eventual disease progression.
The microcantilever arrays are each coated with substances that stick to the HIV and other proteins, which are markers associated with disease progression.
The study didn't find any difference in disease progression a year after treatment between those taking lithium and the control group, researchers said.
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There is no cure but treatments can help slow disease progression.
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She began with patients whose functioning seemed to be deteriorating significantly and more recently has started treating mild patients to see if she can slow the disease progression.
She said a pill to prevent muscle loss would unfortunately not be able to change the genetic cause of muscular dystrophy, but might slow down the disease progression.
Afinitor delayed disease progression in patients with kidney cancer by a modest three months in a 416-patient trial led by Robert Motzer, an oncologist at Memorial Sloan-Kettering Cancer Center.
With a database of recordings available for analysis, more sophisticated algorithms could also be developed that may lead to a scoring system for disease progression based on voice alone.
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But when the researchers reanalyzed the study looking just at those patients with normal kras, they found that in this group Erbitux delayed the disease progression by a much more robust 32%.
Nine children showed greater than a 50% increase in annual rate of weight gain, a statistically significant result, but six children lost weight, perhaps because of disease progression or side effects of the medicine.
However, decreased testing rates mean that older adults are more likely than younger adults to be diagnosed later in their disease progression (i.e. more likely to be diagnosed with AIDS less than a year after diagnosis).
The second thing that we learned is that we were not able to show an impact on time to disease progression in the way that we measured it, which was the time to the next progression event or two lesions in the bone.
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"Kadcyla delivers the drug to the cancer site to shrink the tumor, slow disease progression and prolong survival, " said Dr. Richard Pazdur, director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research, in a statement.
The absence of change over time supports benign disease, while progression suggests a cancer.
While no vaccine exists for hepatitis C, early detection and treatment can curb transmission, limit the disease's progression, and prevent life-threatening complications, including liver cancer.
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The HIV drugs, known as antiretrovirals, halt the disease's progression.
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But doctors and insurers may want proof that Abraxane actually slows the progression of disease, a different measure.
In addition, it should make it easier to assess the impact of new drugs on the progression of disease.
Dr Nicholl stressed that although drugs were now available to slow the progression of disease, there was still no cure for HIV.
Medicines to delay the onset of the disease, slow its progression and, yes, prevent it, can bend the federal health care cost curve downward.
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They are seeking to understand how these neural networks function normally and how changes in the anatomical structures and functioning can shed light on the progression of disease.
People who have both Alzheimer's and vascular disease -- a condition called mixed dementia -- have a more rapid progression of Alzheimer's disease, Cole said.
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Tysabri slowed the progression of the disease in clinical trials by suppressing the immune system.
While not a cure, it can delay the progression of the disease by roughly a year.
He exercises religiously with the hope that it will help stave off progression of the disease.
This is a key element in the progression of chronic disease, and it is, by and large, preventable.
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