Like most drugs, the key will be to differentiate them from known modalities (and other macrocycles), and this will fundamentally depend on a target-by-target, disease-by-disease analysis.
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The paradigm that the team is pursuing is in situ detection, analysis and treatment of disease.
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However, all of these, except perhaps the last, are also likely to be linked to disease and, by careful statistical analysis, Mr Eppig and his colleagues show that all of them either disappear or are reduced to a small effect when the consequences of disease are taken into account.
In an exploratory analysis, women smokers with coronary heart disease (CHD) had a much higher incidence of SCD than women without CHD.
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If the disease is suspected, samples will be taken and sent for analysis by plant health experts.
In healthy women the drugs don't appear to save lives at all, and the evidence they prevent heart disease is weak: Statin takers have only a slightly better chance of avoiding heart disease than women on a placebo, according to a recent analysis.
As of 2008, 23% of adolescents between the ages of 12 and 19 had diabetes or the precursor condition known as pre-diabetes, up from just 9% in 1999, according to a new analysis of national survey data from the Centers for Disease Control and Prevention.
This analysis strongly suggests that mitochondrial mutations are responsible for many cases of Alzheimer's disease.
An analysis of nine medical trials involving over 100, 000 people without a history of cardiovascular disease found that aspirin was more likely to do them harm than good.
The scientists carried out a retrospective analysis that examined foods eaten by 304 men and women, including 72 with Alzheimer's disease, throughout their lives.
With a database of recordings available for analysis, more sophisticated algorithms could also be developed that may lead to a scoring system for disease progression based on voice alone.
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Over the past two years, for instance, he has published studies maintaining the Chantix anti-smoking pill is unsuitable for first-line use (read here and here) and a meta-analysis indicating the mist form of the Spiriva inhaler that is used to treat chronic obstructive pulmonary disease had a 52 percent increase in mortality risk compared with a placebo ( see this).
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Lilly, however, noted that a pre-specified secondary analysis of pooled data showed statistically significant slowing of cognitive decline in patients with mild-to-moderate disease who were treated with its solanezumab compound.
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