But when scientists modify the mice with specific genetic tweaks, they are difficult to replace.
The five- or ten-year veteran invariably takes a certain amount of savvy with her that is difficult to replace.
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Mall owners predict that it wouldn't be difficult to replace Penney stores in the best U.S. malls, such as Aventura Mall in Aventura, Fla.
Delaying a termination after its inevitability has been acknowledged usually happens when the individual is performing well in some aspects of their job, or would be difficult to replace.
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Using the passive-power principle found in crystal radios, the method has proved successful over short distances in places where it is difficult to replace batteries or carry out maintenance.
It will be difficult to replace the legendary batsman, for whom, in the words of my friend and cricket writer, Rohit Brijnath, "decency and determination were not conflicting virtues".
The city sent letters home with students at those schools saying the union was making it difficult to replace bad teachers, explaining that it intends to re-hire a "significant portion" of the school's staff.
Robinson - who departed to English Guinness Premiership side Gloucester while centre brother Jamie joined Toulon - has proved a difficult man to replace in the number 10 shirt.
"The holy pope was able to gain the love of even those who held different opinions and I believe this will be a difficult thing to replace, " said a mourner named as Samir.
Functions are accessed by keystrokes rather than mouse-clicks and require users to invest time learning all the nooks and crannies, making it that much more difficult for them to replace it.
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It is notoriously difficult to take on new workers and replace them.
The US's EMP commission's report explained that to defend against such an attack, it is necessary to build redundant electrical systems and have difficult-to-build replacement parts like turbines on hand to replace ones destroyed by such an attack.
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The federal Treasury cupboard is bare, and it is very difficult to imagine hundreds of millions being appropriated to replace dispensers and underground piping.
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It's becoming increasingly difficult for oil companies to find enough natural gas to replace North American wells that are declining at 30% per year, double the rate of a decade ago.
The decision to replace a presenter is one of the most difficult we ever take.
Because of failures of major financial institutions due to excessive risk taking, lenders became much more cautious, making it difficult for entrepreneurs to invest in new enterprises that would create jobs to replace those that were lost.
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Finding and producing enough oil and gas to replace the oil and gas sold every year is a difficult task for all of the major oil companies.
In the meantime, plant owners have purchased more than 300 pieces of FLEX equipment without waiting for NRC guidelines, which will make it difficult for the agency to later institute standards that could force the industry to replace the equipment.
Was the process difficult because Penny and her tax attorneys had to cook up new tax-avoidance schemes to replace the old ones?
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The goal, Gilead said in its press release, is to create an all-oral treatment for hepatitis C that would replace the difficult treatment with injected interferon and ribavirin, an antiviral pill, along with the fatigue and other side effects they cause.
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"Chris was much loved here and to replace him with someone from London, which they have thrown at them before, was difficult, " Pardew added .
By "disable, " Hill said, the agreement means making it difficult to restart a nuclear program by sealing the facility and removing certain components that would not be easy to replace.
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