Many treatments for acne cause redness, itching and irritation, which make it difficult to continue using them.
It is difficult to continue to come up with new features and functions, especially when trying to outdo what you have done before.
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Under bankruptcy protection the courts can relieve a company of its debts and rescind contracts that make it difficult to continue in business.
The chancellor, Gordon Brown, has acknowledged privately that it will be difficult to continue to increase fuel taxes above inflation in next year's budget.
At some point the small lens of Austrian thought became difficult to continue to peer through, as I looked for perspectives on the larger world.
Tradition had dictated that the holiday be celebrated on the last Thursday of the month, however, this tradition became increasingly difficult to continue during the challenging times of the Great Depression.
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Under our leadership, the Board of Management of Deutsche Telekom made the right decisions and managed properly in the face of very difficult market conditions to continue working successfully in the future.
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"The rapid growth of worldwide electronic commerce and the lack of international consensus on restrictions will further isolate these countries and make it difficult for them to continue these policies, " the report said.
Since the basic Skype service doesn't cost a dime, it threatens to popularize the idea of free calling, and make it difficult for phone companies to continue to charge today's high rates.
However, the report warns that "meeting targets to 2020 will continue to be difficult unless the EU moves to a 30% target for 2020".
If and when a power-sharing government is formed, it will be difficult for the republicans to continue to dodge the question of disarmament.
The Police Federation of England and Wales said in response it would "do everything within our means to ensure that the value of police officers' pensions continue to reflect the difficult job that we do".
Mr Hammond added it could be "very difficult" for the MP to continue as deputy speaker while the matter was being investigated.
We discussed a range of strategic issues, including missile defense, and resolved to continue to work through some of the difficult problems involved there.
It is difficult to believe this reticence can continue indefinitely.
There had been a slight evidence of a risk with naproxen, but the study was stopped because data available from studies indicating a risk with Celebrex made it difficult to convince medical institutions to continue the study.
Those who worry today whether we have what it takes to meet the challenges of this new and difficult century need to look at the people who continue to join their fates to ours.
Drivers continue to face difficult conditions on Dorset's roads over the weekend following heavy snowfall.
But it will be difficult to avoid one if spending shortfalls continue.
For many managers this is a difficult transition and they unconsciously continue to spend time in the more comfortable operational realm of their subordinates.
And in this difficult hour, we will continue to provide it.
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"It will be difficult, if not impossible, to continue the media momentum to the degree that cable news networks have enjoyed in this historic election cycle, " says John Rash, director of media analysis at advertising agency Campbell Mithun.
But I have every confidence that if we are willing to continue doing the difficult work that must be done -- by each of us and by all of us -- then we will leave this struggling economy behind us, and come out on the other side, more prosperous as a people.
We need States to continue to prioritize their funding for ADAPs even in these difficult times, and we need our pharmaceutical company partners, businesses, foundations, and community-based organizations to do their part as well.
No doubt, the remainder of 2010 will continue to be a difficult journey for media companies.
"Our results continue to reflect very difficult market conditions in Europe, " said chief executive Vittorio Colao.
The trend of tackling difficult issues head-on looks set to continue as other countries follow Brazil's lead.
"It's becoming very difficult for these sawmills and the companies to continue operating in this environment, " Burley says.
This goes along with the surveys by the National Federation of Independent Businesses, which continue to show a difficult credit market.
Our hearts are with the families during this difficult time and we'll continue to follow the developments in this tragic case.
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