Uruguay international Diego Forlan and Argentina star Sergio Aguero are likely to spearhead Atletico's attacking threat.
Diego Forlan scored a 52nd-minute penalty to make partial amends for missing from the spot in the first half.
CNN: Real Madrid held goalless in Spain; Inter stay top in Serie A
But Italian referee Pierluigi Collina controversially ruled out the goal and Diego Forlan's late winner merely added to the pain.
Van Bronckhorst opened the scoring in a close encounter with a 35-yard piledriver, before Uruguay's Diego Forlan also struck from range to level.
After Giovanni van Bronckhorst's spectacular opener, Uruguay were gifted an equaliser when goalkeeper Maarten Stekelenburg failed to deal with Diego Forlan's long-range shot.
But Barca's joy was short lived as Diego Forlan quickly pulled one back in the 32nd minute, another superb effort from outside the penalty area.
Earlier in the second-half, Atletico's Diego Forlan had hit the post.
In a first-half lacking in excitement, the Netherlands took the lead when Giovanni van Bronckhorst lashed in, only for Diego Forlan to level from long range.
Diego Forlan finally fashioned a chance for Atletico five minutes before the interval with a shot on the turn that flashed just wide with Reina beaten.
But Diego Forlan pulled one back after 71 minutes -- incredibly Inter's first in 541 minutes -- before the Uruguayan set up Diego Milito for the equalizer.
Atletico Madrid moved further away from relegation trouble with a 2-0 victory at promoted strugglers Xerez, with star strikers Diego Forlan and Sergio Aguero scoring in each half.
Substitute Ruud van Nistelrooy - who had replaced Diego Forlan - broke down the right and coolly squared the ball for Giggs to wrong-foot the keeper before slotting home.
Two of those came in the final 16 defeat to Villarreal and the Spanish side's striker, Diego Forlan, said afterwards that Lovenkrands could be a big star in La Liga.
However, the Spanish team were without top Argentine forward Sergio Aguero who was suspended and that seemed to blunt their attack, with Diego Forlan seemingly at a loss without his strike partner.
Diego Forlan scored the only goal from the penalty spot after 30 minutes after Sergio Aguero had been brought down by visiting keeper Cesar Sanchez to leave Atletico two points clear of Los Che.
In a game of few chances, Uruguay came closest to scoring through a Diego Forlan shot that was saved in the opening half, while they finished the contest with 10 men after substitute Nicolas Lodeiro picked up two bookings.
Diego Forlan capped an impressive performance with two goals - the first a 30-yard deflected strike, the second a well-taken penalty after Luis Suarez had been fouled by goalkeeper Itumeleng Khune, for which he was red carded - and Alvaro Pereira added a late third.
His strike partner Edison Cavani also missed two good opportunities and captain Diego Lugano fluffed a header from a Forlan free-kick early in the second half.
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