They knew what the proteasome looked like, and they designed chemicals they thought would knock it out.
The impartial reason I never liked the Club Glove is that the zipper closure is really annoying, as if not designed with the thought someone would actually try to get a set of golf clubs inside.
Cantalupo took Roberts' mystery-shopper idea--which many operators thought was designed to punish them--and made the data more operator-friendly.
The first of these PPAR receptors was discovered 17 years ago, and for a long time many researchers, including Steve Nissen, thought drugs designed to hit them might prevent heart attacks.
The system was designed by the team that thought up the Game Boy, but the machine was barely portable.
Writing about the competition entries on the Raspberry Pi blog, community manager Liz Upton said PySnap was "well thought out and designed".
But the majority of the warheads owned by India and Pakistan are thought to be designed to be dropped as bombs by aircraft.
The architects of Obamacare designed the scheme without enough thought to how its overlapping incentives would discourage competition on the price of the new coverage.
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House Democrats reportedly thought a Senate bill designed to curb foreclosures was too lenient towards lenders.
It is thought the proposals, designed to raise rental standards, could affect about 200 island properties.
It was designed both to assure Muslims, now thought to number 1.6 billion around the world, that America is not set on a crusade.
An old but creaking system of consensus, the lingering loyalty of bosses and employees to an unaffordable social-welfare model, and a web of constitutional checks and balances designed to prevent even the most fleeting thought of another tyranny, have all made it extraordinarily hard to carry out reform in Germany.
It is thought the mine, which was designed to sink big ships, was originally dropped by parachute during WWII.
"We actually thought the plant was too well designed to have a serious accident, " said former Nuclear Regulatory Commission official Harold Denton.
Google thought so, too, and designed the books project accordingly.
Indeed, many editorialists in the north thought Mr Blair's blizzard of facts was designed precisely to avoid the politically explosive question of whether money should be redirected from Scotland to the north.
The control systems were designed years ago when each utility was an island, without any thought given to bulletproofing against online intrusion once everything was linked together.
The Progressives who designed the city's quirky charter, back in 1925, thought the best way to prevent corruption was to hand as much power as possible to councillors, civil servants and local bigwigs: anybody but the mayor.
There is an older book, 'Battling the Inner Dummy, ' that offers an interesting concept -- 'controlled trauma to induce transformation' and offers this illustration: 'Boot camp ... can be thought of as an example of controlled trauma that is designed to foster traits like loyalty and obedience.
Concerns were also highlighted that more than half of teachers asked thought that "profiling" of P7 pupils - which is designed to help children in their transition to secondary school - was "not very useful".
BBC: New curriculum workload 'too high', EIS union survey warns
"It is something I have thought about a lot, " says Mr. Fidelo, who designed Ms. Williams's garden and connected it to his own, which in turn connects to the yard of a third neighbor, Ken Druse, 62, a garden writer and photographer.
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In 1989 Song Zhenghuan designed a children's rocking chair, or at least that's what he thought it would be.
He said the legislation seems designed to allay public fears of guns in the hands of the mentally ill with little thought given to "the chilling effects" it may have on treatment.
It is thought Bin Laden, or some of his supporters, may have carried out trades designed to profit from falls in stocks likely to be affected, such as reinsurance, airlines and armaments.
Levchin thought this was a terrible idea because it was not the purpose for which they had designed the product.
For the company's finances, the most important new drug is torcetrapib, a new medicine designed to raise high-density lipoprotein (HDL), the "good cholesterol, " which is thought to help clear plaque from the arteries.
Benlysta is delivered directly into a vein (intravenous infusion) and is the first inhibitor designed to target B-lymphocyte stimulator (BLyS) protein, which may reduce the number of abnormal B cells thought to be a problem in lupus.
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