The idea is that permanently restricted funds (or assets) are to be preserved as much as possible (and generally invested) while the income or other benefit of the assets are spent to further the designatedpurpose.
And this space is likely to be filled this year primarily by Intel, which is having what amounts to a coming out party for its recently designated Ultrabooks (upper case on purpose, as the company trademarked the term).
If donors to Komen were concerned about moneys being diverted to Planned Parenthood, those donors could have place restrictions on their gifts that funds not be used for such purpose (or in the alternative, specifically designated for breast cancer research or other use).