Leinster's in-form Sean O'Brien is selected at number eight with open-side David Wallace completing the back row.
Scarlets scored a try first through Regan King, but David Wallace romped over before half-time for Munster.
For the purist the really fascinating battle will take place at the breakdown between Richie McCaw and David Wallace.
Tomas O'Leary took the quick free-kick and David Wallace was able to bludgeon his way over for a try.
But a David Wallace try enabled Munster to move 14-10 ahead at half-time.
Open-side flanker David Wallace is replaced by O'Brien while Leamy gets the number six jersey ahead of Ulster's Stephen Ferris.
Two minutes later, incisive running from David Wallace and Ian Dowling helped Earls convert a left wing overlap for his first try.
David Wallace's score extended the lead before Hodgson's try gave Sale hope.
The back row of David Wallace, Tom Croft and Jamie Heaslip looks quick and powerful and all are playing in their best positions.
But his greatest legacy was arguably introducing O'Driscoll, as well as other stalwarts such as Ronan O'Gara and David Wallace, to international rugby.
One area they really need to make an impact is at the breakdown and David Wallace has to take the lead in this area.
Only Tommy Bowe, Jamie Roberts and David Wallace retain their places from the side which unconvincingly beat a Royal XV in Saturday's tour opener.
O'Gara was also off-target with a long-distance effort and then David Wallace appeared to have crossed the Edinburgh line but no try was given.
David Wallace almost claimed a second try for Munster when he popped out the back of a ruck and raced into the Ospreys' 22.
David Wallace is sadly no longer with us, but I feel certain that he would have considered PMTA 2011-013 for inclusion in the sequel.
It was a bristling encounter at Twickenham that took no prisoners as an all-Lions back row of Stephen Ferris, Jamie Heaslip and David Wallace excelled.
David Wallace's try helped Munster lead 11-3 at half-time with Clermont down to 14 men after Jamie Cudmore's dismissal following a clash with Paul O'Connell.
Tommy Bowe scored an early second-half try but David Wallace and Johne Murphy touched down before O'Connell saw red for a swinging arm on Jonathan Thomas.
Leamy is the only change in the back row where David Wallace is rested with Jamie Healsip remaining at number eight and Stephen Ferris at blind-side.
David Wallace reduced Munster's deficit when he bundled over for the only try of the game in the 51st minute, with Ronan O'Gara kicking the conversion.
And when England just managed to halt a David Wallace charge for the line Youngs took the ball into touch and then threw it into the crowd.
He missed Saturday's win over Italy but now returns to the squad along with Peter Stringer, Kevin Maggs, Anthony Horgan, Simon Best, Paul Connell, Malcolm O'Kelly and David Wallace.
Munster's pack, which includes the likes of Paul O'Connell, Jerry Flannery, John Hayes, Denis Leamy, Donncha O'Callaghan and David Wallace, is regarded as one of the most attritional in Europe.
The opening minutes were marred by an injury to Golden Lions full-back Louis Ludick, who was stretchered off after injuring his knee in a collision with Lions flanker David Wallace.
There is no place in the 23-man squad for Geordan Murphy, while old faithfuls like Hayes, Alan Quinlan, Shane Horgan, David Wallace and Peter Stringer are named on the initial replacements panel.
David Wallace held off the challenge from Martyn Williams to claim the open-side berth with his Ireland colleague Jamie Heaslip completing a back row combination with proven success so far on the tour.
Star fly-half Dan Carter is back for New Zealand and will be looking to perform to his usual high standards - as always it's up to David Wallace to make sure he doesn't.
According to an e-mail put out by the Save the Oaks campaign, two long-time tree-sit photographers, Matthew Taylor and David Wallace, want to publish a photo book documenting the tree-sit and the campaign.
Flanker David Wallace put in some big carries to spark some much-needed life into the game, one of which saw him set up winger Scott Deasy for a darting run into the 22.
Ireland have added nine players to their squad ahead of the South Africa match - Tommy Bowe, Darren Cave, Gavin Duffy, Cian Healy, Kevin McLaughlin, Ronan O'Gara, Devin Toner, Dan Touhy and David Wallace.
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