Coach Vicente del Bosque withdrew his misfiring strike-force of Fernando Torres and David Villa in the 58th minute, bringing on David Silva and Daniel Guiza.
It took over half an hour for David Silva to test Buffon in the Italy goal and after Luca Toni had a dangerous header blocked at the other, Silva shot just wide with a second attempt.
David Silva can't go to another team because he has a contract for five more years.
The Reds had also been linked with Wigan's Lee Catermole and Valencia's David Silva.
James Milner, Mario Balotelli, Jerome Boateng, David Silva, Aleksandar Kolarov are all 24 or younger.
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That enabled David Silva to find Sergio Aguero, but the visitors' top scorer was off-target.
Defender Dedryck Boyata made it 2-0 on the night with a close-range header from David Silva's corner.
Mario Balotelli added a second goal in the first half before David Silva struck in the 70th minute.
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Emmanuel Adebayor gave City a first-half lead from the spot after Richard Stearman had brought down David Silva.
After a quiet opening, the home side threatened when James Dayton's cross was headed off target by David Silva.
Ten minutes in, David Silva's defense-splitting through ball found Samir Nasri, who unleashed a shot that left Spurs goalkeeper Brad Friedel no chance.
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Xavi's club teammate Andres Iniesta threaded a perfect pass through for Cesc Fabregas to cross for David Silva to head home on 14 minutes.
Micah Richards settled a nervy confrontation against Championship side Reading when he rose to power David Silva's corner past Alex McCarthy with 16 minutes remaining.
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Gallacher was called into action again when David Silva tried his luck from distance, the keeper doing well to push the ball out for a corner.
Spain took the lead in the 16th minute after Argentina goalkeeper Sergio Romero saved David Silva's angled shot only for Alonso to capitalize on the rebound.
David Silva set Tevez up to make it 2-0 and he celebrated his 27th birthday with a third goal, converting another penalty after Jerome Thomas handled.
City took the lead just after the hour mark as Toure received a fine pass from Spain star David Silva and scored with a low curling shot.
City and United have used their fortunes to acquire some of the biggest soccer names in the world: Wayne Rooney, Sergio Aguero, David Silva and Rio Ferdinand among them.
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Carlos Tevez and David Silva struck in the first half with Vincent Kompany and an own goal by Newcastle defender James Perch completing a resounding victory for Robert Mancini's team.
Pedro Rodriguez and Xavi Hernandez were absent - along with Cesc Fabregas and Fernando Torres - and in their place came Manchester City's David Silva and Santi Cazorla of Villarreal.
The Premier League and European champions have also been linked with David Silva, Thierry Henry, Klaas-Jan Huntelaar and Roque Santa Cruz, who signed a new four-year contract with Blackburn on Friday.
But Spain appeared to have plenty in hand and with a bit of luck David Silva could have featured among the scorers before giving way to Xabi Alonso in the 77th.
No price tag was revealed but Gomez did confirm that despite Valencia's precarious financial predicament, Villa and fellow Spain star David Silva would not be allowed to go for a reduced price.
Milner - the current Professional Footballers' Association young player of the year - joins Yaya Toure, David Silva, Jerome Boateng, Aleksandar Kolarov and Mario Balotelli in moving to Eastlands this summer.
In the 18th minute, City won a penalty as Carlos Tevez was pulled down by Jos Hooiveld, but Spain World Cup star David Silva saw his weak effort saved by Kelvin Davis.
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Elmander, who started in place of the injured Christian Wilhelmsson, was troubling Spain down the flank but was lucky not to concede a penalty for a nudge on David Silva just before halftime.
City upped the pressure and absolutely peppered the Everton goal with shots for a short spell after the half hour, but the Toffees somehow kept out David Silva, Vincent Kompany and Mario Balotelli.
No sooner had City almost opened the scoring - Lukasz Fabianski reacting brilliantly to keep out David Silva's goalbound flick from a Carlos Tevez cross - than they went down to 10 men.
Valencia stormed out of the blocks in the second half and quickfire goals from David Silva and Nikola Zigic put them in front, before Houssine Kharja drew the Italians level from the penalty spot.
Meanwhile, attacking midfielders like Isco, Juan Mata, Santi Cazorla and David Silva would probably be guaranteed a spot on most top national sides, but have to scratch and claw for playing time with Spain.
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