Mike Yardy was unlucky to be run out by a deflection from the bowler, Daryl Mitchell.
Opener Daryl Mitchell and captain Vikram Solanki fell quickly to Harrison who then polished off the tail.
Daryl Mitchell also kept the hosts' attack at bay with 71 in a five-and-a-half hour spell at the crease.
Worcestershire were led by vice-captain Daryl Mitchell after skipper Vikram Solanki announced his resignation on Thursday after a 241-run defeat by Glamorgan.
Worcestershire lost out-of-form Australian opener Phil Jaques for a duck, but Daryl Mitchell and Moeen Ali extended the lead to 189 by the close.
He had already featured on the staff at New Road way back in 2003, when he made three second XI appearances, featuring alongside Stephen Moore, Steven Davies and future county skipper Daryl Mitchell.
Opener Daryl Mitchell made a hard-earned 20 off 70 balls before being bowled by Andrew Caddick, and he was soon followed back to the pavilion by Moeen Ali, caught at slip by Langer off Willoughby.
Worcestershire's bowlers were backed up by some superb fielding, with Ben Smith taking two difficult chances in the deep and Daryl Mitchell diving to his left at cover to catch Hamish Marshall for eight off Kabir Ali.
Worcestershire soon lost Daryl Mitchell caught behind off Yasir Arafat, but Cameron and Solanki added 77 before Cameron was run out by Luke Wells at cover going for the run that would have taken him to 50.
They were not helped by their failure to take any of the half-chances that came their way, with Mason failing to take a sharp return catch off Suppiah, who also edged Chris Whelan agonisingly past Daryl Mitchell's fingertips.
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