For Debra and Daniel Colvin, owners of a thrift shop in Port Townsend, Washington, the discovery of a rare baseball card brought a thrill.

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That's the goal at a shop at Harvard, where Daniel Branton, a biophysicist, and his colleagues hope to design a better detector by passing DNA--a letter at a time--through a microscopic "nanopore" in a silicon membrane.

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As Daniel Posner, owner of Grapes the Wine Shop in White Plains, N.

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Daniel Wu, who owns a store several miles from Kim's shop in Brooklyn, saw his business spike when a nearby Blockbuster closed.

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That is the goal at a shop a few miles down the road from U.S. Genomics, at Harvard, where biophysicist Daniel Branton and colleagues hope to design a better detector by passing DNA, one letter at a time, through a microscopic "nanopore" in a silicon membrane.

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