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But that was as close as the hosts got as flanker Akapusi Qera fed Simpson-Daniel for his second, and a Burns chip then gave the ex-England wing his treble.
BBC: Cardiff Blues 18-29 Gloucester
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The signatories include former Undersecretaries of State Tom Pickering and Nick Burns, Ambassadors Ryan Crocker, Daniel Kurtzer and Frank Wisner.
BBC: Iran once again at centre of US divide
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Gloucester trailed 10-3 until Freddie Burns struck shortly before the break and James Simpson-Daniel went on to claim a hat-trick in the second half.
BBC: Cardiff Blues 18-29 Gloucester