Dana-Farber's Mayer says he's encouraged that the results are similar in different kinds of tumors.
Already, a coalition was forged between Adams and academics at the Dana-Farber Cancer Institute and the National Cancer Institute.
Researchers at the Dana-Farber Cancer Institute in Boston took Celgene's improved version, Revlimid, and rushed it into myeloma trials.
"This has profound implications, " says researcher Thomas Look of Boston's Dana-Farber Cancer Institute.
The current trial by George Demetri, a GIST expert at the Dana-Farber Cancer Institute, tested SU-11248 in patients who had failed Gleevec.
Winer, director of the Breast Oncology Center at the Dana-Farber Cancer Institute.
"I keep telling them that they need to think more like a biotech, " says George Demetri , an oncologist at the Dana-Farber Cancer Institute.
Demetri of the Dana-Farber Cancer Institute, who codesigned trials of AP23573 after big successes with other fast-tracked pills, such as Gleevec and Pfizer's Sutent.
Gary Gilliland, a hematologist at the Dana-Farber Cancer Institute, used a Web discussion board to recruit hundreds of patients willing to give him genetic samples.
Dr. Eric Weiner of Dana-Farber Cancer Institute in Boston says it's really unusual for a drug to be so effective such a long time after diagnosis.
Under the microscope "it looks like a small bomb went off in the nucleus, " says George Demetri, an oncologist at the Dana-Farber Cancer Institute in Boston.
This study, which was led by Paul Richardson at the Dana-Farber Institute, tested only the sickest patients suffering from a relatively rare cancer called multiple myeloma.
"I don't know anyone who offers women the option of doing nothing, " says Eric Winer, director of the breast cancer program at Dana-Farber Cancer Institute in Boston.
But the debilitating effects on a patient's sexuality are often ignored, said Sharon Bober, director of the sexual health program at the Dana-Farber Cancer Institute in Boston.
"Definitive studies to show it is better than Taxol have yet to be done, " says Eric Winer, a top breast cancer researcher at the Dana- Farber Cancer Institute.
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" Says Robert Mayer , director of the center for gastrointestinal oncology at the Dana-Farber Cancer Institute: "I think it's hard to be anything but enthusiastic about the results.
"That's very impressive, " says Paul Richardson, a myeloma specialist at the Dana-Farber Cancer Institute who has worked on other Celgene-sponsored trials but did not participate in this Thalomid study.
"That is absolutely the case, " agrees Dr. Ann Partridge, clinical director of the Breast Oncology Center at the Dana-Farber Cancer Institute, who also does research on improving health care communication.
"The two different types have fairly dramatically different clinical behaviors, " said Matthew Kulke, director of the carcinoid and pancreatic neuroendocrine tumor program at the Harvard-affiliated Dana-Farber Cancer Institute in Boston.
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Slovenia, and a radiation oncologist at Dana-Farber Cancer Institute.
"You get a broad range from hoaxes, charlatans and self-centered megalomaniacs to extraordinary altruism and everything in the middle, " says George Demetri, an oncologist at the Dana-Farber Cancer Institute in Boston, Mass.
In fact, says Robert Mayer Robert Mayer , director for the center of gastrointestinal oncology at the Dana-Farber Cancer Center, the statins are enticing but less promising than other drugs developed more specifically for cancer.
In a study conducted with the Dana-Farber Cancer Institute and published in Nature Medicine, found that more than half of patients with lung and colon cancer might benefit from the test.
In fact, says Robert Mayer , director for the center of gastrointestinal oncology at the Dana-Farber Cancer Center, the statins are enticing but less promising than other drugs developed more specifically for cancer.
In some cases, drug companies may want to avoid interfering with key proteins to avoid too many unintended side effects, says Marc Vidal, director of the Center for Cancer Systems Biology at Dana-Farber Cancer Institute in Boston.
"These are among the most significant findings in drugs for metastatic cancer in the past five years, " said Eric Winer, director of the breast oncology center at Dana-Farber Cancer Institute in Boston, who wasn't directly involved in the trials.
Working independently, Meyerson's team at Dana-Farber and a group of researchers at Massachusetts General Hospital led by cancer geneticist Daniel Haber analyzed tumor samples from lung cancer patients who'd taken Iressa, and searched for mutations in the EGFR gene.
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