New financial players, like South Africa's Nufcor Group and Evolution Markets, a New York-based over the counter brokerage firm, have become active in uranium contracts in the last couple of years, while deep-pocketed investors have financed new uranium exploration operations.

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Naproxen, the active ingredient in over-the-counter Aleve, has come out of these trials smelling like a rose as far as heart safety is concerned.

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Beginning 16 years ago with the most active stocks, securities authorities required over-the-counter marketmakers to electronically display bids and offers that bettered their own quotes.

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