The pull of national sovereignty will face the push of coordination.

WSJ: As Ireland Flails, Europe Lurches Across the Rubicon

Ms Evans listed the common problems that rare disease suffers face: "Access to timely diagnosis, misdiagnosis, lack of access to information, poor coordination of care, problematic transition from children's to adult services, poor access to treatment, lack of research and inequality of provisions".

BBC: Short debate: Rare diseases