He called for controlled trials, and warned even "natural" products could have side effects.
Medical research commonly employs three kinds of study designs: observational studies, randomized controlled trials (RCTs), and metaanalyses.
He said the next step is to attempt controlled trials in a larger number of patients who need trachea transplants.
Twenty-one of the studies included in the review were randomized controlled trials, which are considered the gold standard for scientific research.
Moreover, he says, based on data from other randomized, controlled trials, he doesn't see big differences between any of the COX-2 drugs.
All of the studies ran for at least a year, and all were randomized controlled trials, the most rigorous type of study.
The Komen Web site cites a meta-analysis of the the two largest randomized controlled trials, one from China and one from Russia.
Two randomized controlled trials in England and the Netherlands have shown that supplementing the diets of young prisoners with omega-3 reduced serious offending by 35%.
Iraqi-controlled trials will also help establish the rule of law in Iraq, claims the administration, providing the cornerstone of a new, sorely-needed legal system.
With so much at stake I was surprised that there had been no prospective, placebo-controlled trials conducted that were funded by an independent source.
Proponents and skeptics alike agree on the need for data from randomized controlled trials to provide better information to guide use of the new procedure.
There have not been any large randomized controlled trials regarding coffee's health benefits, or even to see whether caffeinated or decaf is better for you.
We know from dozens of randomized controlled trials that medications ranging from stimulants to antipsychotics to mood stabilizers are surprisingly effective in reducing aggression in children and adolescents.
Dr. Hartwell, who wasn't involved in the study, said social-network trials aren't likely to replace conventional randomized, double-blinded, placebo-controlled trials, the gold-standard for generating medical evidence.
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And they noted there are nine ongoing, prospective, controlled trials of GLP-1 based therapies with more than 65, 000 subjects, which should hopefully shed light on safety issues.
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We have a set of plausible and interesting hypotheses to work with, and now we need some randomized controlled trials to give us data we can really use.
Results of methodologically rigorous studies are consistent with those obtained from randomised controlled trials, but sensitivity is particularly dependent on appropriately detailed recording and analysis of aspirin use.
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In a brief statement, however, Shire says that recent meetings with the FDA indicated additional controlled trials will be required for approval, although safety was not an issue.
"We know that it causes problems from placebo-controlled trials, " says Garret FitzGerald, a pharmacologist at the University of Pennsylvania, who predicted early on there might be a risk with Cox-2 drugs.
Few types of high-tech scans have been studied in controlled trials to determine whether using them widely saves lives, prevents heart attacks or leads to other concrete improvements in health, NHLBI's Lauer says.
JUPITER, one of the largest trial of statins, with 17, 802 patients, was not published until 2008, nor did we have diabetes data available from many of the other placebo-controlled trials until after 2004.
The safety and efficacy of Belviq were evaluated in three randomized, placebo-controlled trials that included nearly 8, 000 obese and overweight patients, with and without type 2 diabetes, treated for 52 to 104 weeks.
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Several studies that followed large groups of people as they aged have suggested that a diet rich in fish is linked to a reduced risk of dementia and mental decline, but most randomized controlled trials comparing DHA supplements with placebo have found no benefit.
Safety data for KYNAMRO are based on pooled results from four Phase 3, randomized, double-blind, placebo-controlled trials with a total of 390 patients of which 261 patients received weekly subcutaneous injections of 200 mg of KYNAMRO and 129 patients received placebo for a median treatment duration of 25 weeks.
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But randomized controlled clinical trials also are used to prove benefit in big drug studies.
Cannon says only to weigh data from controlled clinical trials, which are expensive and are funded mostly from drug companies.
In June, the British Medical Journal published a major analysis of all the controlled clinical trials that have so far been presented.
When big, controlled clinical trials designed to compare two medicines emerge, the results often resemble what Graham managed with a supposedly less-sensitive study.
Estrogen hormone replacement therapy seemed to have all sorts of benefits based on observational studies, but they vanished under the more rigorous lens of controlled clinical trials.
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