The treatment was common until a randomized controlled trial proved it was actually harming women.
But surgery sometimes goes mainstream without ever being evaluated in a randomized, controlled trial.
If the drug is approved, it may make it difficult to conduct that placebo-controlled trial.
He currently is recruiting post-stroke patients for a randomized, controlled trial comparing error-type treatment to intensive treadmill training.
The link remains controversial because of the lack of a definitive controlled trial.
It is because the government-funded trial was a placebo-controlled, double-blind, randomized controlled trial.
But there has been only one randomized controlled trial studying the effectiveness of taking foods out of so-called elimination diets, Chafen's study said.
"It's not the same type quality control as a controlled trial, " Sequenom's Dr. Bombard said, though he expects doctors to proactively report unusual results.
But I think that before embarking on a large randomized controlled trial he first needs to demonstrate that such a trial would even be feasible.
In Germany, at the hospital of the University of Freiburg, Mathias Berger has recently concluded the first controlled trial of its kind that suggests an answer.
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In healthcare, our gold standard for good evidence is the randomized controlled trial, in which, for example, half the patients receive a new drug and half receive a placebo.
But other doctors, especially oncologists used to the rigorous standards of proof required for big drug trials, note a lack of controlled trial data showing that the procedure extends life.
The Cambridge group will begin a randomized controlled trial next month with 104 children involved, similar to the peanut study done already, but with controls, said researcher Dr. Andrew Clark of Cambridge University Hospitals.
The researchers at Harvard couldn't run a randomised controlled trial where half the participants ate burgers for two decades and the other half didn't, but they could use statistical techniques as the next best thing.
And in a study published last year, researchers in Australia showed in a double-blind, placebo-controlled trial that subjects with suspected gluten sensitivity had substantially fewer symptoms on a gluten-free diet than control subjects who unknowingly ingested gluten.
Researchers don't yet know how to explain these correlations -- and since the study was not a controlled trial, it's not clear whether marijuana or some other factor in marijuana users' lifestyles actually accounted for the beneficial effects.
When trying to find out if something will work - be it a new policy, a new drug, a new teaching method - the gold standard of evidence is what comes out of a properly conducted random controlled trial.
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Because the Framingham Heart Study is not a randomized controlled trial, it's still not clear if vitamin D is the real reason for the link (the vitamin's levels could drop in unhealthy people for other reasons), or if taking a supplement would lower the risk.
But a related Abbott drug, TriCor, failed to prove its benefits in a large randomized controlled clinical trial.
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The investigators are now conducting a randomized, controlled clinical trial of RAGE Control in the outpatient clinic at Boston Children's that adds a cooperative component.
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More substantial and convincing support for such a recommendation to eat cherries as a way to reduce gout flares would ideally emerge from a randomized controlled clinical trial.
In the accepted hierarchy of evidence generation, the results of a randomized, controlled clinical trial usually take precedence over other forms of evidence such as meta-analysis and observational studies.
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For one, the groups noted the analysis is a retrospective study, not a prospective, randomized controlled clinical trial, which many regard as a gold standard for ferreting out safety concerns.
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The authors noted that there has never been a controlled clinical trial of parachutes, and facetiously suggested that one be conducted in which subjects were randomized to jump from a plane either with or without a device.
The FDA approval comes without a controlled clinical trial, which is usually required for a regulatory OK. But in studies, Velcade clearly helped a third of multiple myeloma patients who had failed two or more previous therapies--a stunning result in such a lethal disease.
The randomized, double-blind, placebo-controlled, multi-center trial enrolled 51 patients age 12 to 53 years, including 7 patients age 12 to 16 years, who were maintaining a regimen of maximally-tolerated lipid lowering medications.
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According to a press release, a clinical trial involving 424 patients showed tumors were controlled better by a combination of Erbitux and radiation than radiation alone.
While the Republican-controlled House of Representative could impeach the President, the trial in the Senate would never result in the 67 votes necessary to remove the President from office.
When a skeptic approaches in disbelief that the ears are mind-controlled, Hoffman and Masius offer the ears up for a trial.
U.S. District Judge Lucy Koh also rejected demands from both companies to conduct another trial on different issues over claims that Samsung unfairly used technology controlled by Apple to build its iPads and iPhones to market knockoff products.
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