To make sure the few drug conjugates that reached their prey would destroy them, other researchers like Ravi Chari looked for compounds that were far more potent than standard therapies.
"We currently have more than 25 antibody-drug conjugates in our pipeline and hope this promising approach will help us deliver more medicines to fight other cancers in the future, " Barron said in a statement.
Oral active versions of the narrower differentiation profiles mentioned above (agonists, dual pharmacology, conjugates) could be interesting, but gastric stability and adsorption may preclude those from working optimally and may conflate the risk profile.
This low oral bioavailability shows that in the monkey model, pregnancy does not alter the substantial metabolism to inactive conjugates that occurs in the GI tract and liver after oral ingestion and limits internal exposures to BPA and when compared with injections.