Real-world car buyers should prefer the four-cylinder car, reasoning that the fractional loss of horsepower is more than compensated by the 328i's price, the fuel economy and the comparative lightness.
To these people, it should simply be a matter of shopping for the best price when visiting a physician despite the lack of the constants required for legitimate comparative shopping.
Many conservatives reacted by arguing that comparative effectiveness research is bad, because it is a pretext for government interference in clinical practice, and for price controls.