The most common side effects reported in the trial were mouth ulcers, infections, fatigue and diarrhea.
Common side effects like increased heart attacks--the problem with Vioxx--are hard to discern with conventional clinical trials.
Less common side effects include headache and swelling of a person's hands, feet, legs, face or arms.
More common side effects include dry skin, dry eyes and abnormal results of lab tests such as those of liver function.
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Common side effects of most of these drugs include dry eyes and dry mouth, but drinking water to quench thirst can aggravate symptoms of overactive bladder.
Some common side effects, like nausea, dizziness or slight fatigue, are manageable--especially if the end result is pneumonia or tuberculosis, diseases that were once deadly but now can be treated with antibiotics.
Some of the more common side effects of weight-loss surgery can be difficulty digesting starchy foods and protein, which can lead to other physical conditions including hair loss, fatigue, swelling and muscle weakness.
The most common side effects reported in the study were: were dizziness (seen in 10.4% of those on Ampyra, 2.5% of those on placebo), nausea (3.9% Ampyra, 6.2% placebo), fatigue (5.2% Ampyra, 3.7% placebo), insomnia (5.2% dalfampridine-ER, 2.5% placebo) and arthralgia (2.6% Ampyra, 3.7% placebo).
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Treatment usually involves anti-inflammatory drugs and steroid injections, but side effects are common.
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They are designed to cause less side effects in patients than the more common non-steroidal anti-inflammatory drugs (NSAIDS).
The most common reason for leaving the clinical trial because of side effects was a mix of mental side effects, including depression, anxiety and irritability.
Side effects were benign for a cancer drug, with the most common being severe diarrhea and rashes on the hands and feet.
But interferon-ribavirin regimens clear the most common strain only half the time at most and cause an array of nasty side effects.
The most common cause of the loss of this function in the U.S. is side effects from the powerful antibiotic gentamicin.
"Patients in general clinical practice are older and sicker than the selected patients enrolled in research trials, so deaths from major side effects such as stroke, bleeding and cardiac rupture may be more common, " he said.
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