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Michigan, for example, has met the challenge of its Big Three habit with a combination of farce and failure.
FORBES: Help Mississippi, Not Michigan
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The second compared Vytorin to a placebo, leaving open to interpretation whether it was Zocor alone or the combination that was causing the failure.
FORBES: Merck's Big Vytorin Study Could Change Rules For New Cholesterol Drugs
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Unless the SEC and Financial Industry Regulatory Authority craft strong rules, Mr. Abshure said, a combination of fraud, high failure rates for startups and an "inevitable advertising onslaught of pie-in-the-sky offers" will kill investor confidence in buying shares online.
WSJ: Crowdfunding Efforts Draw Suspicion
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But a heady combination of management incompetence, technical failure and extraordinary incompetence brought the company to earth.
BBC: Dot.com to Dot.bomb
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"The combination of a wholly unrealistic time frame for responses along with a failure to seek an independent and comprehensive market impact assessment from Ofcom demonstrates disregard for the principles of good regulation, " he added.
BBC: BSkyB queries Canvas TV project
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The brash, opinionated Koch, who led the city in the late 1970s and '80s with a combination of determination, chutzpah and humor, died Friday of congestive heart failure at age 88.
WSJ: Legendary NYC mayor Koch dies; Monday funeral set
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The trouble, say critics, is the combination of strict grading with an overloaded timetable and a focus on learning through failure.
ECONOMIST: French education
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The failure to vote or an abstention has the same effect as a vote against the proposed combination.
ENGADGET: DOJ lets waiting period expire on T-Mobile / MetroPCS merger, hints it's good to go
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With early diagnosis many people with heart failure are able to control their condition and live longer and fuller lives with the right combination of drugs, lifestyle and support.
BBC: Killer heart disease on rise
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The complexity that arises from the combination of these activities is reason enough to limit each institution's size, to ensure that an individual failure would not disrupt the economy.
FORBES: Doctor Doom