In combination with the typical spam cycle that sees rises around the Christmas season, it would seem that the scourge of spam will return to its former strengths soon.

BBC: Spam on rise after brief reprieve

But there's precedent for such an approach, since the antiretroviral drugs that now control HIV infections are used in combination to hit the virus at more than one point in its life cycle.

CNN: Possible step toward AIDS vaccine development

The combination of oil dependence and production constraints set up a self-sabotaging boom and bust cycle.

FORBES: The Carbon Bubble