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Psychopaths know at a cognitive level what is right and what is wrong, but they don't feel it.
WSJ: Neurocriminology: Inside the Criminal Mind
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The second problem is that, while it is very unlikely that you will be caught, maintaining a complex story imposes a cognitive load that will make you, at least on a subconscious level, seem less genuine.
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The electroencephalograph picks up cognitive functions in 12 different regions of the brain, showing memory recall and the level of attention paid to visual and aural stimuli.
FORBES: Magazine Article
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In many ways, it seems that the vaccine may help with smoking cessation, but more practically along with medications and other cognitive based therapies to help reinforce any gains made by the vaccine on a biochemical level.
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