Preventing dementia may prove far more tractable than treating patients who are already well into cognitive decline.
In this group, the drug slowed cognitive decline five points on a commonly used 70-point rating scale.
Age, and the cognitive decline that goes along with it, is a very real factor in CEO performance.
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Once their effectiveness has run its course, memory loss and cognitive decline progress unimpeded, and sometimes even accelerate.
Rather, they examined whether fraud could be linked to the cognitive decline that is a natural part of aging.
Dr Eric Karran, from the charity Alzheimer's Research UK, said the exact connection between hearing loss and cognitive decline was still unknown.
To help stave off the cognitive decline of aging, you might want to drop the crossword puzzle and head out for a brisk walk or a bike ride.
WSJ: Exercise Might Beat Puzzles for Protecting the Aging Brain
Becoming socially withdrawn due to hearing loss - such as not going out or struggling with conversation - has been linked to cognitive decline and dementia in the past.
Lilly, however, noted that a pre-specified secondary analysis of pooled data showed statistically significant slowing of cognitive decline in patients with mild-to-moderate disease who were treated with its solanezumab compound.
Recent research suggests that if left untreated, hearing loss might contribute to an acceleration in cognitive decline - relating to our understanding, reasoning and perception skills - as we age.
Eli Lilly, however, is proceeding with its solanezumab compound, which slowed cognitive decline in patients with mild disease, but showed no statistically significant reduction in functional decline ( see this).
And pre-specified secondary subgroup analyses of pooled data across both studies showed a statistically significant slowing of cognitive decline in patients with mild disease, but not in those with moderate disease.
For patients who already have some symptoms of cognitive decline, a positive scan suggests that moderate to frequent amyloid plaques are present in the brain, which is consistent with Alzheimer's disease.
One useful thing to understand is that an elder, even in the early stages of cognitive decline needs to be making plans to allow others to take over the handling of financial matters.
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"We are coming to appreciate the fact that people who remain physically active are less likely to show cognitive decline, " said Stephen Rao, the director of the Cleveland Clinic Schey Center for Cognitive Neuroimaging.
WSJ: Exercise Might Beat Puzzles for Protecting the Aging Brain
According to the guidelines, not participating in contact sports (to avoid concussions) is the only modifiable way to reduce risk for future cognitive decline or potentially CTE in older athletes with multiple prior concussions.
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Meanwhile, Targacept, a firm based in Winston-Salem, North Carolina, is looking at another group of nerve-cell proteins, the nicotinergic receptors, whose activation has been shown to increase alertness and may fend off cognitive decline.
While the primary endpoints of the two pivotal studies conducted were not met, a secondary analysis of the data demonstrated that a molecule acting specifically on amyloid-beta can slow cognitive decline in patients with mild AD.
The researchers noted, however, that "the direction of causation is unclear, " meaning they couldn't tell if a healthier brain was a result of physical activity, or if people showing signs of cognitive decline weren't able to exercise.
WSJ: Exercise Might Beat Puzzles for Protecting the Aging Brain
The question used to shape the draft recommendations, which were posted online Tuesday, is whether hormone therapy should be used by menopausal women to prevent a hypothetical future health event such as heart disease or cognitive decline, Bibbins-Domingo said.
Whether hearing loss is truly a cause of cognitive decline or merely a risk factor associated with the ageing brain, the decline of cognitive abilities into dementia is set to explode financial models of health and social care in Western societies and requires urgent attention.
When Lilly released results of its Phase III Expedition trials two months ago, the findings indicated that cognitive decline was slowed by 42 percent in patients in the early stages of the disease in one trial, and there were also positive signs from another trial, although the showing was not statistically significant.
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Binge drinking twice a month more than doubles cognitive function decline (147%), and memory decline could increase more than fivefold (149%), according to Lang's study.
In fact, Age UK goes as far as arguing it is just as important as the physical activity bit as loneliness is a risk factor for both cognitive and physical decline.
The researchers found those aged 45 to 49 in 1997 experienced a 3.6 per cent decline in cognitive function over the decade.
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In April, a study appeared in The New England Journal of Medicine showing that patients on Aricept and memantine had a less steep decline on cognitive tests than those on Aricept alone.
The NTSB cited research that showed most drivers experience a decline in both cognitive and visual functions with a BAC of 0.05.
And there's no way to halt or reverse the decline of memory and other cognitive abilities once Alzheimer's has been diagnosed.
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