The idea of treating disease by replacing a defective gene with a working copy gained credence in 1990 with the success of the world's first gene therapy clinical tests against a rare condition called severe combined immunodeficiency (SCID).
Biogen Idec and partner Elan had to pull their multiple sclerosis drug Tysabri after patients in clinical trials came down with a rare viral disorder that can lead to brain damage or death.
In a rare peek at the costs of clinical trials, Peto discloses how much the studies he is involved with cost.
Jack Lief , Arena's chief executive, points out that the heart valve side effects were rare, and that a big clinical trial could settle the issue.
And his efforts were backed up by clinical finishing and solid defence on the all too rare occasions when it mattered, most crucially from Leeds old boy Richie Mathers.
Although the beneficial effects of high-potency statins have been well-characterized in clinical trials, these same trials have lacked the power to illuminate rare but potentially important adverse events.
FORBES: High Potency Statins Linked To Increased Risk For Acute Kidney Injury
Clinical use of Cox-2 drugs in association with cancer is still relatively rare.
Novartis is confronting such concerns head-on with large clinical trials that try to tease out potential side effects and will take the rare step of directly comparing Prexige, formerly known as Cox-189, to both Celebrex and Vioxx.
The Rare and Imported Pathogens Laboratory at Porton Down, is providing diagnostic support to clinical teams to help them handle suspected anthrax cases.
Because the disease is so rare, the drug was tested in only 56 patients in its late-stage clinical trials.
FORBES: Pfizer Enters Market For Super-Expensive, Ultra-Rare Disease Drugs -- With A Price Cut
It was an analysis of published clinical trials that raised the first big questions about drug-coated stents causing heart attacks in rare cases.
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