Part of the problem is that clinical trials have too often focused on white men.
Last week the Guardian published a short extract from my new book about problems in the pharmaceutical industry, in which I talk at length about the problem of withheld clinical trial data.
FORBES: The Real Scandal Is Not Acknowledging That Drugs Do Work
The clinical trial that pointed out a problem used doses of double or quadruple that.
He has not hyped vorapaxar, and he better have been caught off guard by the bad news, because otherwise there would be a serious problem with the vorapaxar clinical trials.
Roy suggests this problem is responsible for poor clinical outcomes seen in Medicaid beneficiaries.
Professor Paul Salkovskis, a leading clinical psychologist, said part of the problem was society's squeamishness about going to the toilet.
If it turns out to be more common in the real world than it was in clinical trials, this could be a problem for Vertex.
The problem is there are no clear clinical guidelines for when a patient should be kept under observation.
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The third problem, that the results of clinical trials may be irrelevant to the real world, has several components.
Once more: I find it hard to understand how someone who worked as head of Research and Development at Pfizer could possibly deny this basic, universally recognised problem of poor external validity in clinical trials.
FORBES: The Real Scandal Is Not Acknowledging That Drugs Do Work
"The issue is starting to be recognized as a legitimate object of clinical attention, as well as an economic problem, given that a great deal of non-essential internet use takes place at work, " said Dr Aboujaoude.
Tracey Parsons, a clinical psychologist working as clinical adviser on the project, said the major problem with mood diaries was that people simply don't fill them in.
Medical students will interact with Watson on challenging cases as part of a problem-based learning curriculum and in hypothetical clinical simulations.
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"New studies indicate this is a global problem, " says Kimberly Young, a clinical psychologist who wrote the first book on the subject of Internet addiction, "Caught in the Net, " and founded the Center for Internet Addiction Recovery in Bradford, Pennsylvania.
The problem is that Lucentis was subject to all the clinical and regulatory hurdles required for approval to treat wet AMD, and the manufacturer (Genenetech in the US, Novartis elsewhere) has had to monitor all subsequent use for adverse events.
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Common side effects like increased heart attacks--the problem with Vioxx--are hard to discern with conventional clinical trials.
Pfizer had already enrolled thousands of adults in Trovan clinical trials but had not tested it yet on children, which posed a problem.
More specifically, believing that the diagnostic certainties of addiction can explain the very real, new, and quite perplexing problem of people getting trapped by online behaviors goes against current science and clinical experience.
Expensive clinical trials that come just as a drug is losing its patent protection are a real problem for drugmakers.
The problem is that it's not real, says Joanna Lipari, a clinical psychologist at the University of California, Los Angeles.
"That led to the idea that one could give most or all of the radiation closer to the original tumor bed and that would solve the problem, " says George Sledge, a past president of the American Society of Clinical Oncology and co-director of the breast-cancer program at Indiana University Simon Cancer Center, in Indianapolis.
Judging by the clinical way in which the Heat dissected the Bucks in this series, that isn't likely to be a problem.
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