Hundreds of scientific papers are deliberately hidden by publishing them all together in such totally obscure journals such as the Clinical Investigator and Molecular Aspects of Medicine, but only rarely in mainstream medical journals.
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One clinical trial investigator mailed in "before" and "after" X rays of a patient whose tumor vanished after being treated with Iressa, exclaiming that he had never seen this before.
Generally, people who have mild acne can be treated with topical treatments, and those with moderate acne through a combination of topical and systemic treatments such as isotretinoin, says David Pariser, dermatology professor at Eastern Virginia Medical School in Norfolk and principal investigator of clinical trials with Oslo-based specialty drug maker Photocure, which is developing a photodynamic treatment for moderate-to-severe acne.
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"You trade one kind of risk for another, " says Dr. Silberstein, who has served as an investigator on several companies' clinical trials.
Merit Cudkowicz, an ALS researcher at Harvard Medical School who was an investigator on a standard lithium clinical trial, said social network-generated data can offer valuable insights, but she cautioned that the PatientsLikeMe study was not a substitute for more rigorous studies.
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Lieberman was the primary investigator for a government-funded clinical trial that showed there was little difference in how long patients stuck with the new class of antipsychotics, like Zyprexa and Risperdal, vs. the older, cheaper variety, such as Haldol.
Adele Schneider, director of clinical genetics at Einstein Medical Center Philadelphia and principal investigator of the current research, says the study came together after she saw three families of Irish descent who all had children with Tay-Sachs in the past few years.
However, at a Medtronic analyst meeting at the conference, lead trial investigator Gust Bardy from the Seattle Institute for Clinical Research insisted that such an approach would not be medically valid.
Giaccone is serving as the principal investigator for NovaRx's third and perhaps final clinical trial, which will include 700 patients who have been treated with chemotherapy and whose tumors are neither growing nor shrinking.
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