The clinical effects include runny nose, chest pain, shortness of breath, confusion, followed by vomiting, loss of bowel and bladder function, convulsions, loss of consciousness, and suffocation.
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Patients receiving the new drug treatments in clinical trials experienced side effects including headache, nausea and fatigue.
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So far officials of the National Institutes of Health say they've seen no serious side effects in clinical trials and that study subjects who have been immunized have generated a good response.
The most common reason for leaving the clinical trial because of side effects was a mix of mental side effects, including depression, anxiety and irritability.
The treatment was pulled from clinical trials because of side effects.
Pfizer's share price plunged after higher-than-expected mortality and side effects reported during a clinical trial led it to scrap a drug it had been developing since 1992.
We also uncovered evidence that the antidepressant was addictive, that it could make some adults self-harm and become suicidal and that clinical trials had shown that these effects were also possible in children who took the drug.
The study - which focused primarily on Seroxat - looked at clinical trial data and reports of adverse effects and found possible links between SSRI antidepressants and violent behaviour.
An antibiotic, Ketek, had side effects and multiple problems with its clinical trials, including outright fraud.
As co-chairs, we are personally committed to this work, having first-hand community and clinical experience in seeing and treating the devastating effects violence has on the lives of women and their families.
People with HIV often remain asymptomatic for years, and conventional wisdom is that treating such people brings little clinical benefit while exposing them to unpleasant side effects such as nausea, vomiting and diarrhoea.
Oliker, a clinical psychologist whose research has focused on the lasting effects of childhood in adulthood.
But in clinical trials, dapagliflozin did have some serious side effects.
The company says the study was based on a summary of separate studies, when the proper way to determine the drug's effects is to conduct long-term clinical trials of patients taking Avandia.
The clinical trials of the vaccine showed the main side effects being headache and sore arms in a small percent of patients, and those rates were almost exactly the same as those for a sham injection.
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Novartis is confronting such concerns head-on with large clinical trials that try to tease out potential side effects and will take the rare step of directly comparing Prexige, formerly known as Cox-189, to both Celebrex and Vioxx.
Jack Lief , Arena's chief executive, points out that the heart valve side effects were rare, and that a big clinical trial could settle the issue.
It appears to be superior to standard antibody-based quality-control tests currently used for that purpose, but such scientific advances will need to undergo extensive validation studies before they can be considered a reliable predictor of effects in vivo and eliminate the need for clinical data.
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Although the findings of the studies are mostly consistent in showing a similar magnitude hazard ratio, estimates of the effectiveness of sipuleucel-T are imprecise due to the relatively small total sample size of the clinical trials, and unmeasurable biases due to potential confounding effects of frozen salvage product and post-progression treatments.
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One is meta-analysis, in which the results of clinical trials are pooled together to try and tease out small effects of a treatment.
So far, clinical trials for the H1N1 vaccine have not indicated adverse side effects beyond what are experienced with the seasonal flu vaccine, Sebelius said.
Earlier this month, the FDA rejected Wyeth's Pristiq, an antidepressant that was being tested for menopausal symptoms, saying it wants additional clinical trials on the drug's heart and liver side effects.
This avoids the painful round of injections and side effects a woman normally has to undergo in the standard clinical IVF cycle.
Although the beneficial effects of high-potency statins have been well-characterized in clinical trials, these same trials have lacked the power to illuminate rare but potentially important adverse events.
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While this allows medicine to engage in clinical innovation, it can present patients with concerns about relative safety and whether adverse effects have been fully described.
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The drug, still undergoing clinical trials in the U.S., seems to have the same side effects as the other COX-2 inhibitors, but in tests against morphine, ketorolac (Toradol) and a placebo, Dynastat was superior to morphine and the placebo and comparable to ketorolac in potency and duration.
In the 1990s clinical trial used to approve IL-2, 4% of patients died from side effects.
Dr. Eric Topol of the Cleveland Clinic and his colleagues reanalyzed data from pivotal clinical trials conducted by the drug companies and found that both Vioxx and Celebrex might have cardiac side effects.
In the studies, Cholestin had no side effects, except for a few cases of flatulence, according to Joseph Chang, vice president of clinical affairs at Pharmanex.
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Alas, as tangible and compelling as the effects of these nondrug interventions may be, they often lack the deep pharma pockets required for the clinical trials that will bring doctors on board.
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