In closing statements, prosecution lawyers asked the jury for a "cold, clinical analysis of the issues".
BBC: Harry Redknapp arrives at Southwark Crown Court on 2 Feb
Where Mr Baverez is clinical in his analysis and unsentimental in style, Jean-Marie Rouart, on the other hand, transports the reader into an altogether different world of nostalgia for a France long-gone.
GlaxoSmithKline 's Avandia was the best-selling diabetes drug in the world until Steven Nissen of the Cleveland Clinic published an analysis of clinical trial data that showed a heightened risk of heart attacks, strokes and cardiovascular death for patients on the drug.
The FDA analysis of posted clinical trial data from May 2012 appears to contradict the BMJ study.
FORBES: PhRMA Is Not Effective in Improving the Image of the Pharma Industry
In the next generation of DNA sequencing, routine DNA analysis in the clinical setting is not far off.
It was an analysis of published clinical trials that raised the first big questions about drug-coated stents causing heart attacks in rare cases.
However, in a subsequent analysis, where clinical investigators excluded three patients selected for the device group because they had a stroke before the device was implanted, the results were statistically significant.
WSJ: Doctors Debate Whether Strokes Be Prevented With a Heart-Plug Procedure
The technique of pooling disparate clinical trials, called meta-analysis, has become the most powerful weapon of drug safety researchers.
Unfortunately for weight loss drugs, clinical researchers tend to favor an analysis that includes those who stop therapy precisely because it is tougher and harder for drug companies to game.
That could mean the results are close, but Novartis will have to wait until the trial is finished to file with the FDA. Another expected interim analysis from a second clinical trial will not be made public as was previously planned.
In June, the British Medical Journal published a major analysis of all the controlled clinical trials that have so far been presented.
An analysis in the Journal of Clinical Oncology last year found that studies that have looked at people who had used cell phones 10 years or longer tended to find the strongest risk of tumors.
The Oxford University researchers who conducted the trial recently published an analysis of the results of completed clinical trials of cholesterol-lowering drugs in The Lancet.
One is meta-analysis, in which the results of clinical trials are pooled together to try and tease out small effects of a treatment.
They asked Roche for full clinical study reports, with study protocols, the reporting analysis plan, the statistical analysis plan and individual patient data so that all they could more fully determine what could be concluded from the studies.
In the accepted hierarchy of evidence generation, the results of a randomized, controlled clinical trial usually take precedence over other forms of evidence such as meta-analysis and observational studies.
FORBES: Glaxo Alleges Errors In Nissen's Critique Of FDA's Handling Of Avandia
For one, the groups noted the analysis is a retrospective study, not a prospective, randomized controlled clinical trial, which many regard as a gold standard for ferreting out safety concerns.
FORBES: The Confusion Over A Pair Of Diabetes Drugs And Pancreatitis
Priorities and clinical strategies should be set by medical experts based on scientific evidence and cost analysis, and those decisions need to be insulated from the kinds of financial incentives and disincentives that special interest groups exert.
The key difference is that clinical trials are much more rigorous, and as much as possible rely on objective, quantitative analysis to measure improvement, as opposed to field trials, which are more reliant on patients' subjective reactions.
Instrumental variable analysis attempts to do just that, standing in contrast to the standard approach used in clinical studies.
Based on an analysis of leads returned to the company and recent fluoroscopic images of implanted leads still in clinical use, St.
Many experts who conduct clinical trials have stated that it is not unusual for complex trials to take longer than expected for proper analysis.
"The record, in short, is one of careful analysis at every stage, a continued commitment to research and prompt and decisive action in response to clinical-study results, " the scientists say.
Fleming also argues that Peto's analysis of the IMPROVE-IT and SHARP studies raises "important concerns" about the integrity of those clinical trials.
应用推荐