The drug's future could be complicated because it also lowers good cholesterol and raises bad cholesterol.
Torcetrapib aims to raise good cholesterol, or high-density lipoprotein, by blocking the cholesterol ester transfer protein.
As expected, mipomersen also resulted in significant reductions in app B, total cholesterol, and non-HDL cholesterol.
If you have slightly elevated cholesterol, or even normal cholesterol, should you take statins?
Liver problems are a common problem for cholesterol drugs, because the body makes cholesterol in the liver.
Because LDL cholesterol is a major risk factor for heart disease, it's the main focus of cholesterol-lowering treatment.
Even former President Bill Clinton was said to have stopped taking his cholesterol medicine once his cholesterol levels got low.
One big hope is Zetia, a cholesterol pill that would be added onto other cholesterol-lowering medicines to make them stronger.
The addition of Kynamro helps to reduce low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B, total cholesterol, and non-high density lipoprotein-cholesterol (non HDL-C).
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Low-density lipoprotein, the bad cholesterol, carries cholesterol fat to the arteries, where it gets stored as plaque in the artery wall.
Among them were the highly touted cholesterol drug Tredaptive and a combo pill for patients with diabetes and high cholesterol called MK-0431E.
Academic researchers studying families with gene defects that caused bad cholesterol levels to soar had uncovered key biology responsible for cholesterol production.
Diabetes UK says that because of the existence of statins - cholesterol-lowering drugs - it is relatively easy to control high cholesterol.
It's the drug that can lower your bad cholesterol or LDL cholesterol.
The colossal failure cast a pall over the good cholesterol field and raised questions over whether doctors understand how good cholesterol works.
Unlike other cholesterol medicines, Isis' experimental mipomersen will be targeted at patients whose high cholesterol is caused by a relatively rare genetic disease.
"Cholesterol is still needed to clog the arteries, but TMAO changes how cholesterol is metabolized like the dimmer on a light switch, " he said.
People with high levels of good cholesterol appear to be somewhat protected against heart disease, even if their bad cholesterol levels are high.
These studies had led to new cholesterol guidelines in the U.S. that suggested lowering low-density lipoprotein (LDL), or bad cholesterol, to extemely low levels.
He said the Cabernet Sauvignon grapes had high levels of resveratrol - which increases levels of "good" cholesterol and slows production of "bad" cholesterol.
Although not large, this difference in cholesterol concentration is comparable to that achieved in studies involving alteration of intake of dietary fat or cholesterol.
Right now, the gold standard in cholesterol medication is a class of drugs called the statins, which prevent the liver from making cholesterol from fat.
Robert Spiegel, Schering's chief medical officer, points out that Nissen himself has said that lowering bad cholesterol, or LDL, is the "cornerstone" of cholesterol therapy.
We saw that most vividly with torceptrapib, the Pfizer drug that raised the good cholesterol, lowered the bad cholesterol and increased the risk of death.
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But they fly in the face of the conventional wisdom about heart disease: Basically, that good cholesterol is always good, and bad cholesterol is always bad.
The results could revive hopes for a notorious class of drugs that aim to boost good cholesterol particles, which help clear cholesterol out of the arteries.
Drugs to raise good cholesterol to clear arteries, to prevent cholesterol from sticking to the artery wall and to decrease inflammation in the arteries have all failed.
Changes issued today by the National Cholesterol Education Program (NCEP), to be published in tomorrow's issue of the journal Circulation, advocate lowering cholesterol in even more patients.
Vytorin combines Zocor, a generic that is the most prescribed cholesterol-lowering drug in America, with a newer medicine called Zetia that works differently from other cholesterol drugs.
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