The Liverpool trial aims to find out if a tailored exercise programme and improved fitness after chemo-radiotherapy translates to a shorter stay in hospital.
Chemo-radiotherapy specifically degrades muscle mass, and depresses the function of mitochondria, the tiny structures that act as the boiler room of the cell, generating energy.
Now that Wadsworth is cancer-free and feeling healthy after seven rounds of chemo and a double-mastectomy, her attitude flipped.
Various chemo drugs and interleukin-2 produced nerve damage and other nasty side effects and didn't solve the problem.
Back in 2001, a plan was in the works for a study comparing Erbitux combined with chemotherapy to chemo alone for front-line use.
For example, Bristol-Myers and ImClone are now in trials combining Erbitux with yet another colon cancer chemo drug, oxaliplatin from Sanofi-Synthelabo (nyse: SNY - news - people ).
Now Genentech says the drug also extends the lives of patients with certain types of lung cancer for two months when combined with chemo, based on an 877-patient clinical trial.
However, many U.S. treatment centers do use chemo and radiation as part of post-surgery treatment.
They decided that I probably ought to get the retina re-attached before I started the chemo.
And some docs prescribe Zytiga off-label for patients who cannot tolerate chemo.
The promise of new chemo drugs got a boost in the spring when studies found that the cancer drug Taxotere, made by Sanofi-Aventis, extended survival in prostate cases from 16 months to 18 months, the first time any chemo agent had been found to extend the life of prostate patients.
Avastin in colon cancer only works when combined with older chemo drugs, despite all the hype about it being a less-toxic targeted agent.
These are the patients who are in the top one per cent of costs because they were in a car crash that resulted in a hundred thousand dollars in surgery and intensive-care expenses, or had a cancer requiring seven thousand dollars a week for chemo and radiation.
Chemo drugs killed the tumor, while antisense went to its roots, blocking the production of PKC-alpha proteins.
Next step: another final-stage trial with 600 more patients injected with antisense and Gemzar, Lilly's chemo drug for lung cancer.
Besides an acne-like rash and diarrhea, there were relatively few side effects--another thrilling find for doctors and patients alike, given the devastating side effects of chemo (hair loss, severe nausea, damage to the immune system).
In stark contrast to ImClone, which rashly tested Erbitux in only 120 patients with no control group, AstraZeneca enrolled 2, 000 patients in late-stage trials to compare how long patients survive on a combination of chemotherapy and Iressa versus chemo and a placebo.
He saw how his dad went through chemo and radiation treatments, but never complained, never felt sorry for himself, and continued to work full-time to provide for his family.
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