Named Spanish Player of the Year in 2007, Cazorla joined Malaga in 2011 following two stints with Villarreal.
David Villa, Santi Cazorla, Marcos Senna also scored for Spain, but Dani Guiza had his effort saved by Buffon.
Olivier Giroud scored twice, while Lukas Podolski, Santi Cazorla and Theo Walcott were also on target for the Gunners.
Arsenal paid more than double that to sign French striker Olivier Giroud, Spanish midfielder Santi Cazorla and German forward Lukas Podolski.
Cazorla's arrival at Arsenal follows the club's summer signings of Germany forward Lukas Podolski and France international striker Olivier Giroud.
Striker Van Persie was sold to Manchester United, with the likes of Lukas Podolski, Santi Cazorla and Olivier Giroud joining the Gunners.
Fabregas -- he replaced Torres after 54 -- and Santi Cazorla, who substituted for Andres Iniesta on 63, injected more pace into Spain's impressive counterattacking.
Pedro Rodriguez and Xavi Hernandez were absent - along with Cesc Fabregas and Fernando Torres - and in their place came Manchester City's David Silva and Santi Cazorla of Villarreal.
Fifth-placed Arsenal moved to within a point of Tottenham as Spain midfielder Santi Cazorla scored both goals in a 2-1 victory over third-bottom Aston Villa to relieve the pressure on manager Arsene Wenger.
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Meanwhile, attacking midfielders like Isco, Juan Mata, Santi Cazorla and David Silva would probably be guaranteed a spot on most top national sides, but have to scratch and claw for playing time with Spain.
Pablo Hernandez came on for Cazorla and was the recipient of a delightful pass by Villa and ought to have done better with his shot, an uncertain effort which McGregor was well placed to save with his feet.
Arsenal moved above Everton into fifth with a 1-0 win at Sunderland as Santi Cazorla scored the only goal, while Swansea went above Liverpool in seventh after beating bottom team Queens Park Rangers 4-1 thanks to two goals from Michu, who now has 15 in the EPL this season.
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