Among those who got placebo, 13.7% had one of those types of cardiovascular problems.
Survivors face many long-term effects of treatment, from secondary cancers to cardiovascular problems to cognitive defects.
Weight-loss stimulants speed up metabolism but can cause strokes, heart attacks and cardiovascular problems.
Merck faced a similar situation after it reported in 2000 higher rates of cardiovascular problems from Vioxx.
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In one big study, a similar drug called Lopid had slashed the risk of cardiovascular problems by 22%.
It was already known that being "apple-shaped", as opposed to "pear-shaped", added to the risk of developing cardiovascular problems.
The warning should say the drugs could increase the risk of cardiovascular problems and sudden death, the panel said.
In this pandemic of portliness, some 300, 000 people die each year of obesity-related diseases such as diabetes and cardiovascular problems.
Moreover, it had been shown to cause fewer cardiovascular problems than Vioxx.
IMPROVE-IT tests whether lowering LDL to previously unheard-of levels will prevent heart attacks and strokes in people who have already had cardiovascular problems.
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PM10 is produced by exhaust fumes as well as tyre and brake wear and can cause asthma, cardiovascular problems, lung cancer and premature death.
While too much sodium is associated with cardiovascular problems, too little potassium can have the same effect, so potassium chloride has a double benefit.
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To further cloud the matter, heart attacks and other cardiovascular problems will only be counted in the first 14 days after patients stop their painkiller.
He also criticizes the study for only taking into account heart attacks and other cardiovascular problems that occurred within two weeks after patients stopped taking Vioxx.
Everyone has heard of statins: they are a class of cholesterol-lowering drugs that offer clear benefits in people who already have suffered heart attacks or other serious cardiovascular problems.
The people who spent more than four hours in front of screens in their spare time had a 2.3-fold risk of cardiovascular problems compared with those who spent less than two hours.
Years ago, in addition to providing relief for menopause symptoms, hormone therapy was thought to offer protection against cardiovascular problems, osteoporosis and dementia, so doctors routinely prescribed it to otherwise healthy women.
Despite the additional calories, results showed that participants eating the Med way had a 30 percent lower risk of major cardiovascular problems compared to those who were told to follow a low-fat diet.
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Last December, the NEJM editors published a strongly worded "expression of concern" arguing that Merck left out relevant data about cardiovascular problems that occurred among patients taking Vioxx in the trial, called Vigor.
The New England Journal of Medicine released internal Merck memos indicating that Merck knew more about cardiovascular problems caused by Vioxx than it revealed when it published a giant study of the drug in 2000.
They then looked at Danish health registers up until the end of 1998 to look at how many of the men and women had cardiovascular problems, and up to 2001 to see how many had died.
Between 5% and 10% of patients with cardiovascular problems develop clots, estimates Donald Baim, an interventional cardiologist at Brigham and Women's Hospital in Boston, who is also a scientific adviser to OmniSonics, as well as a shareholder.
This summer, an article in the Journal of the American Medical Association said that both Vioxx and its main competitor, Pharmacia (nyse: PHA - news - people) drug Celebrex, may cause heart attacks and other cardiovascular problems in rare cases.
In a separate New England Journal editorial, University of Washington epidemiologist Bruce Psaty and Wake Forest University's Curt Furberg are also harshly critical of Pfizer for not publicizing details until just a few weeks ago of another study that found hints of cardiovascular problems with Celebrex in 2000.
Stuhr said older clients are at higher risk of diabetes and cardiovascular disease and also may have problems like arthritis, back pain or muscle tears.
All of these problems increase the risk of cardiovascular disease, which kills 946, 000 Americans a year.
Pfizer had aimed to develop its own ACAT inhibitor, but the drug failed to show a benefit. (See: Pfizer's Cardiovascular Failure) But some of the problems with that drug may have come from the fact that it interacted with Lipitor, preventing cholesterol from being lowered enough.
That extra weight can lead to serious health problems, including type 2 diabetes, cardiovascular disease and psychosocial issues such as peer discrimination or poor self-esteem.
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Novartis' response to the concerns that Cox-2 inhibitors might cause heart problems is to run extra clinical trials to try and prove that its drug does no cardiovascular damage.
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