You have to dry the vaccine without killing the cells in it, and you have to make the particles small enough to be inhaled but not so small that they are exhaled.
The particles had to be small enough to navigate the twists and turns through the mouth, throat and trachea but not so small that they would be easily exhaled.
But tornadoes are so small, relatively, that they are still too small for the models to see.
But for someone so small, it is making it big name for itself.
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But the default was so small that Greece was still left with a crushing debt burden.
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But his majority was so small that he could not heal the divisions she had created on Europe.
But because it is so small, the Circle regularly books singer-songwriters and indie talent that the bigger clubs pass up.
There was a slight increase in heart risk for naproxen users, but the increase was so small that it may have been a chance occurrence.
But the pods are so small and tight that he can barely split them open with his penknife blade to show me the bean inside.
They're glad to have a place to lay their heads near their homes, but the trailers are so small, people have to take turns getting dressed in the morning.
"One of the most fascinating aspects of Enceladus is that it's so very small as icy moons go, but so very geophysically active, " said Dr Bob Brown, from the University of Arizona, US, and team leader for Cassini's visual and infrared mapping spectrometer.
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No one seems to like big government any more, but Friedman wanted a state so small it would cost less than 15% of national income.
Omidyar has sold only 5% of his Ebay shares so far, but has small investments in conventional stocks and bonds, as well as a few investments in high-tech startups.
CytoDyn believes they have the intellectual property and experiential know-how to develop PRO 140 thru completion on their own, but, like so many other small biotechs, obvious synergies and scale are created by joining forces with the right partner to bring a drug with so much potential to market.
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But the costs of administering so many small loans is also considerable.
Big things come in small packages, but so do big changes.
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For example, he says that cash management is a life or death issue for a small company, but so is health care for your workers.
But even so, just having a small chance to get the top pick can be a huge distraction for NBA teams one that prevents them from making any long-term plans.
So small effects yes, but we can really only see them at the margins.
But most candidate countries are small, so expansion could push over-representation to absurd levels.
At its peak in 15 years or so, payouts would be but a small fraction of 1% of the nation's net wealth.
This is a classic market where a service is extremely expensive but in being so can only serve a small percentage of the addressable market.
That may be so, but the surpluses have been small, and they require you not only to include offshore energy but to ignore capital spending.
This has been the best approach with consumer cases where the individual harm is small, but egregious, so a class action was necessary to right this wrong.
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With Ecuador, the IMF apparently thought it could demonstrate that, indeed, it was aware of moral hazards--but did so with a country that was small enough not to have damaging repercussions to financial markets.
Our direct financial exposure to those governments and their financial institutions is quite small, but Europe is so large and so closely integrated with the U.S. and world economies that a severe crisis in Europe could cause significant damage by undermining confidence and weakening demand.
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China is famous for its factories, but less so for its ability to churn out small businesses.
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Motorola first designed something so small it was wearable, but company anthropological researchers determined that Paris Hilton is often averse to wearables, including clothing.
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But the radiation deaths will likely be a number so small, compared with the tsunami deaths, that they should not be a central consideration in policy decisions.
The more volatile the returns are, the more distorted the numbers will be so this is an extreme example but even a small difference in returns can have a huge impact.
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