Guardiola eventually brought on striker Villa and playmaker Iniesta, though midfielder Busquets was not used.
Motta's reaction following the dismissal, man-handling Busquets in protest, only fanned the flames of a high-octane encounter.
It resulted in a corner and it took a fine save low down from Almunia to deny Sergio Busquets.
However, Adrian leveled in the 39th minute with a header after an error by Sergi Busquets, who returned from suspension.
If you're going to count them as La Masia products, you can't really count Pedro, Puyol and Busquets, as well.
But a second penalty was awarded after veteran Italy international Alessandro Nesta was controversially adjudged to have tugged Sergio Busquets' shirt.
Great teams have all-rounders in that role, guys who are also skillful passers, like Manchester United's Michael Carrick or Barcelona's Sergio Busquets.
WSJ: Mortella's Approach Paying Off for Italian Soccer's Fiorentina
In the first match against Italy Sergio Busquets had played slightly in front Xabi Alonso in the centre of the Spain midfield.
Barca possessed the ball for 80% of the game, and first-half goals from Sergio Busquets and Andres Iniesta gave it the lead.
This time Busquets played slightly behind Xabi Alonso and to the right.
Pedro is often referred to as a La Masia product, but he joined at 17, as did Puyol and defensive midfielder Sergio Busquets.
Pirlo advanced and slipped past the attentions of Busquets to play a lovely ball in for Di Natale to run onto and score.
On the half-hour mark Sergio Busquets rifled a shot at goal, which fell to Villa who spun his marker and shot from close range.
David Villa, Andres Iniesta and Sergio Busquets started on the bench as La Liga leaders Barca beat Real Zaragoza thanks to a Seydou Keita strike.
Protecting a first-leg 3-1 lead, Inter were forced to play more than an hour a man short after Thiago Motta saw red for a hand-off on Sergio Busquets.
Barcelona also was missing defenders Carles Puyol and Javier Mascherano and midfielder Sergio Busquets because of injuries, and left back Jordi Alba because of a suspension for yellow-card accumulation.
Gallas failed to last until half-time with a recurrence of his calf injury and another blow arrived just before half-time when Fabregas was harshly booked for tangling with Busquets.
Sergio Busquets forced Real goalkeeper Diego Lopez into his first save of the match with a shot from the edge of the area that took a deflection off Germany international Sami Khedira.
The Brazilian, already on a booking, did indeed raise a hand when defending the ball and he certainly made contact with Busquets' face as he did so, but a straight red card appeared a harsh decision.
The closest you get to a Barca villain is midfield enforcer Sergio Busquets or wingback Dani Alves, both of whom have a penchant for taking a tumble to win a free kick, while Busquets is known for the odd dirty tackle.
Longtime stalwarts Xavi Hernandez and Xabi Alonso, who have an incredible 225 caps between them, may be the wrong side of 30, but the trio of Javi Martinez (24), Sergio Busquets (24) and Cesc Fabregas (25) are just hitting the prime of their careers.
应用推荐