Former England captain Nasser Hussain believes coach Duncan Fletcher will face the biggest test of his regime in the build-up to the third Test at Perth.
The Wales coach, who played almost 150 games as hooker for Waikato between 1986 and 1994, and his team had spent much of the second Test build-up in the Hamilton community on a charm offensive.
He's attacking rocketry the way he would assemble software: design, build, test and repeat in rapid-fire succession to quickly determine what works and what doesn't.
The CHMP was also concerned by liver test results in patients taking Kynamro showing a build-up of fat in the liver and increased enzyme levels, and was not convinced that the company had proposed sufficient measures to prevent the risk of irreversible liver damage.
With those risks, inevitably, goes the chance of failure in the test program and the need to adapt designs, build work-arounds and make modifications to subsequent production articles.