Buehrle settled down, allowing only Nix's third-inning walk before Adams singled leading off the fifth.
Wells had been 24 of 50 (.480) against Buehrle but went 0 for 3 against him.
The starting pitchers are Houston right-hander Roy Oswalt and left-hander Mark Buehrle of the Chicago White Sox.
Buehrle settled down, allowing only Nix's third-inning walk before rookie David Adams singled leading off the fifth.
Wilson and the White Sox Mark Buehrle, a pair of borderline aces, the best available.
Clay Buchholz (6-0) pitches for Boston against Mark Buehrle (1-2) in the second game of the three-game series Saturday.
Mark Buehrle (2-3, 5.51 ERA) is scheduled to start Saturday night for Toronto.
Making the 400th start of his career, Buehrle allowed three runs and eight hits in a season-high seven innings.
Aaron Loup relieved Buehrle after the first three batters in the seventh had hits, including an RBI double by Romine.
Shortstop Jose Reyes and pitchers Josh Johnson and Mark Buehrle were dealt to Toronto, and manager Ozzie Guillen was fired.
"When you run into hot pitching like that, you try to shut them down as long as you can, " Buehrle said.
Just consider five Miami Marlins traded to the Toronto Blue Jays, Josh Johnson, Mark Buehrle, Jose Reyes, Emilio Bonafacio, and John Buck.
A. Dickey, Mark Buehrle, Josh Johnson in trades and signing Melky Cabrera.
The Marlins are the only other 2012 team to field just five starters: Anibal Sanchez, Carlos Zambrano, Josh Johnson, Ricky Nolasco and Mark Buehrle.
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"Buehrle was rolling along, too, " Blue Jays manager John Gibbons said.
All the players, with the probable exception of Buehrle, carry risks.
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Cano had an RBI groundout in the first then struck out and grounded back to Buehrle in the fifth to hold New York to a run.
Mark Buehrle, Josh Johnson and Jose Reyes are the three brand names in the trade, but each has varying levels of interest to the Blue Jays.
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Buehrle (1-1) has lost seven straight decisions against the Yankees dating to 2004 with the Chicago White Sox and is 1-9 in 14 starts against New York.
Buehrle (1-3) has not beaten the Yankees since April 10, 2004, when he was with the Chicago White Sox and is 1-10 against New York in 15 starts.
"I didn't feel as good as the last game, but (I was) still making some pitches until the last inning: first pitch double, then a good bunt, " Buehrle said.
Wells opened the scoring with a homer against Mark Buehrle in the second that hit the left field foul screen, his fifth of the season and second in two days.
Romine and Brett Gardner had run-scoring hits, Robinson Cano hit an RBI grounder and Jayson Nix had two sacrifice flies in dropping Buehrle to 1-10 in 15 starts against the Yankees.
Loria had appeared hellbent on putting together a superstar, win-now lineup last offseason, bringing in Reyes, Buehrle and closer Heath Bell to join Johnson, Stanton and longtime franchise star Hanley Ramirez.
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Vernon Wells homered again against Mark Buehrle, and Francisco Cervelli also connected for New York, which overcame a 3-0 deficit to beat the Blue Jays for the third time within a week.
The Miami Marlins are set to trade Jose Reyes, Josh Johnson, Mark Buehrle, John Buck and Emilio Bonifacio to the Toronto Blue Jays in exchange for Yunel Escobar and a handful of prospects.
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The left-handed Buehrle, pitching against Kuroda for the second time within a week, struggled against a team that came in hitting .199 against lefties, yielding five runs and seven hits in 5 1-3 innings.
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