In animal tests Guilford's PARP inhibitors can reduce stroke-induced brain damage by up to 70%.
In animal tests Guilford's PARP inhibitors reduce stroke-induced brain damage by up to 70%.
Tests in primates had suggested NA-1 prevented brain cells dying when a stroke starved them of oxygen.
Speaking to BBC News online, Prof Buchan said the focus of this research was on "ways to keep brain cells alive" which could have impacts beyond stroke - such as in Alzheimer's disease and spinal cord injuries.
Low doses appeared to offer some protection against stroke damage - reducing the area of the brain affected by 30%.
Much of the brain damage suffered during a stroke is caused by the release of so-called "free radical" molecules.
Cerovive is the first drug to target the toxic compounds that are produced by the starved brain cells--and it can be used as long as six hours after the stroke.
Designed for stroke patients and those suffering from brain or spinal cord injuries, these so-called medical micropower networks (MMN) use a set of implanted electrodes and a wearable wireless controller to stimulate the muscles of a paralyzed user.
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Osofsky-McGonigle had aphasia, a common outcome of stroke in which parts of the brain related to language, including reading, writing and talking, are damaged.
While a deeper understanding of neuro-plasticity is extremely relevant for people who have suffered from a stroke or other traumatic brain injury, what has piqued my interest most is its application for those of us whose brains already work perfectly well.
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As for whether it works for sharpening the brain or minimizing damage from a stroke "the jury is out, " says Catherine Ulbricht, co-founder of Natural Standard Research Collaboration, a Cambridge, Mass.
Besides stroke, he says, drugs aimed at the new targets could prove useful for treating spinal cord injuries, amyotrophic lateral sclerosis, even epilepsy--because the same toxic cascade that occurs after a stroke also happens after many other types of brain damage.
Besides stroke, Dr. Suzdak says, drugs aimed at the new targets could prove useful for treating spinal cord injuries, Lou Gehrig's disease or even epilepsy--because the same toxic cascade that occurs after a stroke also happens after many other types of brain damage.
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