Bosingwa played alongside his new Chelsea team-mates Ricardo Carvalho and Paulo Ferreira at Porto.
Bosingwa was born in Kinshasa, Congo, but moved to Portugal with his parents when he was a child.
Chelsea's defensive options have been stretched of late with Cole, Branislav Ivanovic and Jose Bosingwa all ruled out.
Nani struck the bar after cutting inside and was then hauled down by Bosingwa as he chased the rebound.
However it was almost a disastrous start as a sloppy Jose Bosingwa pass could easily have gifted Wolves a first-minute opener.
First Anelka curled a shot wide from just outside the box, then Lampard planted a header over the bar from Bosingwa's cross.
And while Boro failed to put pressure on the ball, Kalou, Malouda and full-backs Jose Bosingwa and Wayne Bridge in particular, exploited the space.
The home side claimed a penalty four minutes later when Henry appeared to be tugged back by Bosingwa, but the referee waved away their appeals.
Goalkeeper Petr Cech made some crucial saves in the game, while Jose Bosingwa's marking of Lionel Messi prevented the Argentine having a major impact on the game.
The foul on Jo occurred inside the centre circle, with Terry's centre-back partner Ricardo Carvalho covering the play and full-back Jose Bosingwa also sprinting back to defend.
O'Neill later claimed Villa should have had a penalty early in the first half after England striker Gabriel Agbonlahor went down in the box when challenged by Jose Bosingwa.
Jose Bosingwa fired in a cross from the left towards Joao Moutinho but it arrived at an awkward height for the Sporting Lisbon midfielder, who diverted the ball over the bar with his thigh.
Suddenly, the Blues looked a hungrier and more purposeful outfit, with Ashley Cole and Jose Bosingwa providing width in the final third and Frank Lampard probing busily behind Didier Drogba, Nicolas Anelka and Florent Malouda.
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Having failed to score the early goal that would have settled their nerves, Chelsea's play became increasingly ragged, with a failure to get behind the visitors prompting Drogba and Jose Bosingwa into speculative efforts from distance.
After missing out on the English title to Manchester United on Sunday, Avram Grant's side have gained a small measure of revenge by beating United in the race to sign Bosingwa, who was also attracting interest from Liverpool and Aston Villa.
Lampard, Bosingwa and Terry all went close before the break and although Hamill saw a decent strike blocked by John Terry, the Blues then went ahead when Ramires reacted quickly to lash the ball into the top corner following Mata's corner.
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