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An infection in the bone could lead to potential issues with bone healing, along with possible spread of infection throughout the body as well.
FORBES: Kevin Ware's 'Gruesome' Injury
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Complications are rare, but can include wound-healing difficulties, infection and lack of bone healing.
CNN: Broken leg
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Her husband took Jesse to the emergency room, and doctors determined that he had a classic case of mastoiditis: an infection of the mastoid bone, just behind the ear.
CNN: But is it really an emergency? When to take a child to the ER
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He endured round after round of chemotherapy, one infection after another and a bone marrow transplant.
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The widely publicized patient, Timothy Brown, was treated for leukemia with a bone marrow transplant that happened to come from a donor with a genetic mutation that makes immune cells resist HIV infection.
MSN: Two more men with HIV now virus-free. Is this a cure?
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Once that is done, the organ (in this case a kidney) and the bone marrow are transplanted and the patient is confined for a fortnight in a sterile environment to protect him from infection while his new, mixed immune system boots up.
ECONOMIST: Organ transplants