Inactivity, poor nutrition, and age-related changes, all help to reduce bone mass at the rate of approximately 1% per year after age 40.
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This important role is quite helpful reduce the age-related decline in bone mass.
Of the millions of people with sickle-cell disease in the world, only some 300 have received a bone marrow transplant because of age (doctors won't perform the procedure on patients 16 years and older) and donor-matching problems.
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But because everyone's bones get thinner as they age, it is difficult to know in advance which patients will develop full-fledged bone disease.
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