Or it might be hitting its proper target (the enzyme gamma secretase) but in too blunt a fashion.
Early in the primaries, he faced a blunt question from a New Hampshire teenager.
With these finely honed tools, reliance upon a blunt instrument like a database of payments to physicians appears unwarranted, and perhaps even risks doing more harm than good.
Prosecutors did not pursue the death penalty, so Gerhartsreiter could face a maximum sentence of 25 years to life in prison for the murder conviction, plus two additional years because the jury also found that he personally used a blunt object and a sharp instrument as weapons.
Her style at the General Assembly was a model for John Bolton's, confrontational and blunt to a degree, and the present ambassador, as he resigned amid general hooting, candidly acknowledged his debt to her.
You can use electrocautery, a hook, a pair of scissors, a sharp-tip dissector, a blunt-tip dissector, a right-angle dissector, or a suction device.
Their weak returns leave these insurers a blunt choice: either find a way to make their business lines more profitable or shut them down.
Blunt was a virtually innocent victim, we were told, and the only villain was the press.
To be blunt, a sales tax cartel is bad news for tax policy and bad news for privacy.
Mr. Paxton has sandy brown hair and a blunt manner of speaking tempered by a wicked sense of humor.
Blunt, a onetime protege of former House Majority Leader Tom DeLay has been around the longest of the GOP leaders.
He was also characteristically blunt on a host of other Chrysler issues.
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Mr Blunt, a former Army officer who was making calls to servicemen in Afghanistan, said he was shocked and distressed when he found out from police that his phone had been hacked.
Over the next couple decades, image and message were simplified into a blunt black-and-white icon of a brutal face with the words Obey Giant emblazoned beneath.
His words were echoed by Vicky Ford MEP, a fellow Conservative politician, who warned that the bonus cap was a "blunt tool" which set a "bad precedent".
Boehner, who represents a southwest Ohio district, also sent a blunt letter to his colleagues in which he sounded a theme of reform and admitted his party "took a pounding" Tuesday.
This otherwise - Kirk's plan just pull up 18, 000 gang members and arrest them seems like kind of a blunt way to go about this as opposed to a precise targeted effort.
The action was described in the report as "a blunt and indiscriminate instrument" that was "never intended to be implemented and does not represent a responsible way" for the country to realize deficit reduction.
But a blunt announcement that the government was going to scrap thousands of jobs in the service would have risked a serious backlash, with the public backing the firefighters.
But Labour peer Baroness Lister said it was a "blunt" instrument that "reflected badly" on a government which "claims to be the most family friend government ever".
He acknowledges that Facebook is top dog in social, but is more than a little blunt in claiming that the online rival is doing a "really bad job" with its products (don't hold back now, Larry).
No doubt, the sequester is a blunt, inefficient, arbitrary, even stupid way to cut outlays.
FORBES: Republicans Mislead Their Base With Handwringing Over Sequester Defense Cuts
And I'll be blunt -- a lot of members of Congress, this is tough for them.
But the law is, at best, a blunt and unpredictable instrument for disciplining bosses.
Karl Breilmann, meanwhile, was attacked with a blunt instrument and died from head injuries.
BBC: NEWS | UK | England | Merseyside | Internet hope for unsolved cases
Smoked salmon so tender you carved it by rubbing it with a blunt knife.
It is increasingly seen as a blunt instrument for all but the most dangerous individuals.
But most still reckon that it is at best a blunt instrument for fighting poverty.
His address lays out a blunt in-your-face, take-no-prisoners program that half the American people reject.
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