Her experiments suggest that blocking the protein hit by gamma secretase will kill brain cells over the long term.
One of the most promising ways of increasing strength is by blocking a protein called myostatin that slows down muscle growth.
By blocking a protein called the vascular endothelial growth factor (VEGF), it prevents arteries from growing around tumors, literally starving them.
Torcetrapib aims to raise good cholesterol, or high-density lipoprotein, by blocking the cholesterol ester transfer protein.
They then tested drugs to see which might be effective in blocking the action of this protein.
Enbrel works by blocking a long-mysterious protein in the immune system known as tumor necrosis factor, or TNF.
The new drug, called a CETP inhibitor, works by blocking the action of a protein which lowers levels of "good" cholesterol in the body.
All the drugs work by blocking the cholesterol ester transfer protein.
He argues that the amount of amyloid in patient brains doesn't correlate much with dementia, and blocking tau, a second protein that accumulates in the brain cells of demented patients, as his company is doing is a much better way to go.
Most researchers are focusing on blocking the formation of amyloid-beta protein or removing it from the brain, either before or after deposits are formed.
Researchers got excited about HDL in the late 1990s because they found a way to raise it by blocking a molecule called cholesterol ester transfer protein (CETP).
The public has mostly focused on Erbitux's ability to slow tumor growth by blocking epidermal growth factor receptor, a key growth-promoting protein that is overabundant in many cancer cells.
His lab showed this protein to be the receptor for VEGF, and that blocking the receptor stunted the growth of tumors in lab animals.
All of the cholesterol drugs known as statins work by blocking the same drug target, a liver enzyme (enzymes are a kind of protein).
The drugs work by blocking an enzyme called factor 10a that helps spur the production of a crucial clot-promoting protein called thrombin.
Working with Yale University neurologist Stephen Strittmatter, who cloned the Nogo gene, Biogen Idec has created a counterinsurgency protein that acts as a sponge to soak up copies of Nogo and other growth-blocking proteins in the spinal cord before they can bind to the receptor.
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