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Shaw, 36, replaces Louis Deacon in the second row while fellow Wasp Joe Worsley is named on the blind-side flank in place of Tom Croft.
BBC: England call-up for Erinle & Shaw
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At blind-side flanker , England duo Tom Croft and James Haskell have their supporters, but both Wood and Davies believe picking Ireland's David Wallace and Wales veteran Martyn Williams, both open-sides , together could be the way to neuter South Africa.
BBC: Lions Watch - Pundits' verdict
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It's quick and with Jamie Heaslip and Tom Croft playing at number eight and blind-side respectively, it also gives the team a couple more line-out options.
BBC: Jeremy Guscott column
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Dr Tom Pey, chief executive of the Royal London Society for the Blind and Dorton House School, in Seal, had asked for a conductor to help him on arrival.
BBC: Blind Eurostar passenger left stranded in Brussels
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Haskell, normally a blind-side flanker, replaces Moody on the open-side, while Wood comes in for Tom Croft and Deacon replaces Courtney Lawes.
BBC: Six Nations: Tindall leads England as Wood handed debut